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文件

SML0198

Sigma-Aldrich

非诺多泮 甲磺酸酯

≥98% (HPLC)

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别名:
Fenoldopam methanesulfonate
经验公式（希尔记法）:
C16H16ClNO3 · CH4O3S
CAS号:
67227-57-0
分子量:
401.86
EC 号:
266-612-7
MDL编号:
MFCD04112986
PubChem化学物质编号:
329825223
NACRES:
NA.77

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

储存条件

desiccated

颜色

white to tan

mp

271 °C (lit.)

溶解性

DMSO: ≥15 mg/mL at ~60 °C

储存温度

room temp

SMILES字符串

CS(O)(=O)=O.Oc1ccc(cc1)C2CNCCc3c(Cl)c(O)c(O)cc23

InChI

1S/C16H16ClNO3.CH4O3S/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21;1-5(2,3)4/h1-4,7,13,18-21H,5-6,8H2;1H3,(H,2,3,4)

InChI key

CVKUMNRCIJMVAR-UHFFFAOYSA-N

基因信息

human ... DRD1(1812)

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应用

Fenoldopam mesylate may be used to study dopamine D1-mediated cell signaling.

生化/生理作用

Fenoldopam mesylate (FM) is considered as an effective therapeutic agent to prevent the onset of postoperative AKI (PO-AKI). In healthy cats, FM can stimulate diuresis and be well-tolerated. This benzazepine-derivative is regional specific and does not cause cerebral vasodilation.
Fenoldopam mesylate is a selective dopamine D1 receptor agonist used as an antihypertensive agent. It is an agonist for D1-like dopamine receptors and binds with moderate affinity to α2-adrenoceptors. It has no significant affinity for D2-like receptors, α1 and α-adrenoceptors, 5HT1 and 5HT2 receptors, or muscarinic receptors. Fenoldopam mesylate causes peripheral vasodilation by stimulating dopamine-1receptors and α2-adrenoceptors, increasing renal blood flow.

特点和优势

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302 - H317 - H319

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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51 What is the value of Non-Dialytic therapy in acute kidney injury
Evidence-Based Practice of Critical Care E-book: Expert Consult, 359-359 (2010)
The pharmacokinetics of intravenous fenoldopam in healthy, awake cats
O'Neill KE, et al.
Journal of Veterinary Pharmacology and Therapeutics, 39, 202-204 (2016)
Pharmacokinetics and pharmacodynamics of fenoldopam mesylate for blood pressure control in pediatric patients
Hammer GB, et al.
BMC anesthesiology, 8(1), 6-6 (2008)
Sagar U Nigwekar et al.
Seminars in nephrology, 31(6), 523-534 (2011-11-22)
Acute kidney injury (AKI) is common in hospitalized patients and is associated with significant morbidity and mortality. The incidence of AKI is increasing and despite clinical advances there has been little change in the outcomes associated with AKI. A variety
C A Bloom et al.
Journal of veterinary pharmacology and therapeutics, 35(3), 224-230 (2011-07-08)
Fenoldopam is a selective dopamine-1 receptor agonist that causes peripheral arterial vasodilation, increased renal blood flow, and diuresis. Enthusiasm exists for the use of fenoldopam in nonpolyuric kidney injury in dogs, although pharmacokinetic data are lacking. The purpose of this
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