SML0198
非诺多泮 甲磺酸酯
≥98% (HPLC)
别名:
Fenoldopam methanesulfonate
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关于此项目
经验公式（希尔记法）:
C16H16ClNO3 · CH4O3S
CAS Number:
分子量:
401.86
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to tan
mp
271 °C (lit.)
溶解性
DMSO: ≥15 mg/mL at ~60 °C
储存温度
room temp
SMILES字符串
CS(O)(=O)=O.Oc1ccc(cc1)C2CNCCc3c(Cl)c(O)c(O)cc23
InChI
1S/C16H16ClNO3.CH4O3S/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21;1-5(2,3)4/h1-4,7,13,18-21H,5-6,8H2;1H3,(H,2,3,4)
InChI key
CVKUMNRCIJMVAR-UHFFFAOYSA-N
基因信息
human ... DRD1(1812)
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相关类别
应用
Fenoldopam mesylate may be used to study dopamine D1-mediated cell signaling.
生化/生理作用
Dopamine D1-receptor agonist; Antihypertensive
Fenoldopam mesylate (FM) is considered as an effective therapeutic agent to prevent the onset of postoperative AKI (PO-AKI). In healthy cats, FM can stimulate diuresis and be well-tolerated. This benzazepine-derivative is regional specific and does not cause cerebral vasodilation.
Fenoldopam mesylate is a selective dopamine D1 receptor agonist used as an antihypertensive agent. It is an agonist for D1-like dopamine receptors and binds with moderate affinity to α2-adrenoceptors. It has no significant affinity for D2-like receptors, α1 and α-adrenoceptors, 5HT1 and 5HT2 receptors, or muscarinic receptors. Fenoldopam mesylate causes peripheral vasodilation by stimulating dopamine-1receptors and α2-adrenoceptors, increasing renal blood flow.
特点和优势
This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
51 What is the value of Non-Dialytic therapy in acute kidney injury
Evidence-Based Practice of Critical Care E-book: Expert Consult, 359-359 (2010)
Pharmacokinetics and pharmacodynamics of fenoldopam mesylate for blood pressure control in pediatric patients
Hammer GB, et al.
BMC anesthesiology, 8(1), 6-6 (2008)
The pharmacokinetics of intravenous fenoldopam in healthy, awake cats
O'Neill KE, et al.
Journal of Veterinary Pharmacology and Therapeutics, 39, 202-204 (2016)
John H Rundback et al.
Journal of vascular surgery, 54(2), 575-579 (2011-07-12)
Contrast-induced nephropathy (CIN) has been extensively studied since the 1950s due, in part, to its devastating adverse events. The intellectual push for additional investigation into pathogenesis and prevention has heightened in recent years due to increased utilization of contrast enhanced
Sagar U Nigwekar et al.
Seminars in nephrology, 31(6), 523-534 (2011-11-22)
Acute kidney injury (AKI) is common in hospitalized patients and is associated with significant morbidity and mortality. The incidence of AKI is increasing and despite clinical advances there has been little change in the outcomes associated with AKI. A variety
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