SML0198
非诺多泮 甲磺酸酯
≥98% (HPLC)
别名:
Fenoldopam methanesulfonate
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C16H16ClNO3 · CH4O3S
化学文摘社编号:
分子量:
401.86
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
266-612-7
MDL number:
产品名称
非诺多泮 甲磺酸酯, ≥98% (HPLC)
InChI key
CVKUMNRCIJMVAR-UHFFFAOYSA-N
InChI
1S/C16H16ClNO3.CH4O3S/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21;1-5(2,3)4/h1-4,7,13,18-21H,5-6,8H2;1H3,(H,2,3,4)
SMILES string
CS(O)(=O)=O.Oc1ccc(cc1)C2CNCCc3c(Cl)c(O)c(O)cc23
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to tan
mp
271 °C (lit.)
solubility
DMSO: ≥15 mg/mL at ~60 °C
storage temp.
room temp
Quality Level
Gene Information
human ... DRD1(1812)
正在寻找类似产品? 访问 产品对比指南
相关类别
Application
Fenoldopam mesylate may be used to study dopamine D1-mediated cell signaling.
Biochem/physiol Actions
Dopamine D1-receptor agonist; Antihypertensive
Fenoldopam mesylate (FM) is considered as an effective therapeutic agent to prevent the onset of postoperative AKI (PO-AKI). In healthy cats, FM can stimulate diuresis and be well-tolerated. This benzazepine-derivative is regional specific and does not cause cerebral vasodilation.
Fenoldopam mesylate is a selective dopamine D1 receptor agonist used as an antihypertensive agent. It is an agonist for D1-like dopamine receptors and binds with moderate affinity to α2-adrenoceptors. It has no significant affinity for D2-like receptors, α1 and α-adrenoceptors, 5HT1 and 5HT2 receptors, or muscarinic receptors. Fenoldopam mesylate causes peripheral vasodilation by stimulating dopamine-1receptors and α2-adrenoceptors, increasing renal blood flow.
Features and Benefits
This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Pharmacokinetics and pharmacodynamics of fenoldopam mesylate for blood pressure control in pediatric patients
Hammer GB, et al.
BMC anesthesiology, 8(1), 6-6 (2008)
The pharmacokinetics of intravenous fenoldopam in healthy, awake cats
O'Neill KE, et al.
Journal of Veterinary Pharmacology and Therapeutics, 39, 202-204 (2016)
51 What is the value of Non-Dialytic therapy in acute kidney injury
Evidence-Based Practice of Critical Care E-book: Expert Consult, 359-359 (2010)
A D Knapton et al.
Methods and findings in experimental and clinical pharmacology, 32(7), 489-497 (2010-11-12)
Exposure of the vasculature to vasodilators, pharmaceuticals and industrial chemicals may lead to injury of the blood vessel wall in animals. Vascular injury may begin with changes in the permeability of vascular endothelial cell and vessels, resulting in possible hemorrhage
Shetal H Padia et al.
Hypertension (Dallas, Tex. : 1979), 59(2), 437-445 (2011-12-29)
Renal dopamine D(1)-like receptors (D(1)Rs) and angiotensin type 2 receptors (AT(2)Rs) are important natriuretic receptors counterbalancing angiotensin type 1 receptor-mediated tubular sodium reabsorption. Here we explore the mechanisms of D(1)R and AT(2)R interactions in natriuresis. In uninephrectomized, sodium-loaded Sprague-Dawley rats
商品
We offer many products related to dopamine receptors for your research needs.
我们可提供多种多巴胺受体相关的产品，满足您的各类研究需求。
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持