SML0199
Metaxalone
≥98% (HPLC)
别名:
5-(3,5-Dimethylphenoxymethyl)-2-oxazolidinone, 5-[(3,5-Xylyloxy)methyl]-2-oxazolidinone, AHR 438, Metaxalon, Metazalone, Metazolone, NSC 170959
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关于此项目
经验公式（希尔记法）:
C12H15NO3
化学文摘社编号:
分子量:
221.25
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
216-777-6
MDL number:
InChI key
IMWZZHHPURKASS-UHFFFAOYSA-N
InChI
1S/C12H15NO3/c1-8-3-9(2)5-10(4-8)15-7-11-6-13-12(14)16-11/h3-5,11H,6-7H2,1-2H3,(H,13,14)
SMILES string
Cc1cc(C)cc(OCC2CNC(=O)O2)c1
assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
DMSO: ≥2 mg/mL (warmed to 60 °C)
storage temp.
−20°C
Quality Level
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Application
Metaxalone may be used in cell signaling studies.
Biochem/physiol Actions
Metaxalone is a muscle relaxant. The mechanism of action of metaxalone in humans is not fully understood. It was suggested that it acts through general central nervous system depression.
Metaxalone is effective to relieve pain due to acute skeletal muscle pain caused due to musculoskeletal conditions and sprains.
Muscle relaxant (skeletal)
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Justin L Poklis et al.
Journal of analytical toxicology, 28(6), 537-541 (2004-11-02)
The case history and toxicological findings of a fatal multi-drug overdose involving metaxalone (Skelaxin) are presented. Gas-liquid chromatography with flame-ionization detection and gas chromatography-mass spectrometry were used to determine the following drug concentrations (mg/L) in aortic blood: 19 mg/L metaxalone;
Rakshit Kanubhai Trivedi et al.
Scientia pharmaceutica, 80(2), 353-366 (2012-08-17)
A simple, sensitive and reproducible reversed phase ultra performance liquid chromatography (RP-UPLC) coupled with a photodiode array detector method was developed for the quantitative determination of metaxalone (META) in pharmaceutical dosage forms. The method is applicable to the quantification of
Peter P Toth et al.
Clinical therapeutics, 26(9), 1355-1367 (2004-11-09)
Low back pain is a leading reason for primary care visits. Many treatment options are available, but some lack scientific support. The aim of this review was to discuss the etiology of low back pain and the relative risks and
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