SML0202
DPH
≥98% (HPLC)
别名:
5- [3-（4-氟苯基）-1-苯基-1H-吡唑-4-基]-2,4-咪唑烷二酮, 5-乙内酰脲
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关于此项目
经验公式（希尔记法）:
C18H13FN4O2
化学文摘社编号:
分子量:
336.32
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to tan
溶解性
DMSO: ≥10 mg/mL
储存温度
2-8°C
SMILES字符串
Fc1ccc(cc1)-c2nn(cc2C3NC(=O)NC3=O)-c4ccccc4
InChI
1S/C18H13FN4O2/c19-12-8-6-11(7-9-12)15-14(16-17(24)21-18(25)20-16)10-23(22-15)13-4-2-1-3-5-13/h1-10,16H,(H2,20,21,24,25)
InChI key
MPQWYPLPWGUMJE-UHFFFAOYSA-N
相关类别
应用
DPH 可用于 c-Abl 酪氨酸激酶介导的细胞信号传导研究。
生化/生理作用
DPH 是一种强效细胞渗透性 c-Abl 激活剂。DPH 与肉豆蔻酰结合位点结合，导致 c-Abl 激酶活性的激活。该化合物可刺激 c-Abl 及其下游底物 Crk 的磷酸化。
DPH 结合并改变了 c-Abl 酪氨酸激酶肉豆蔻酰结合站点的构象。表现出刺激 c-Abl 活化的强效酶和细胞活性。
强效细胞渗透性 c-Abl 激活剂
特点和优势
这种化合物是激酶磷酸酶生物学研究的特色产品。点击此处发现更多特色激酶磷酸酶生物产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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