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SML0208

KYP-2047

Name: KYP-2047
Brand: SIGMA

≥95% (HPLC), Prolyl oligopeptidase inhibitor, oil

别名:

(2S)-1-[[(2S)-1-(1-氧代-4-苯基丁基)-2-吡咯烷基]羰基]-2-吡咯烷腈

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关于此项目

经验公式（希尔记法）:

C₂₀H₂₅N₃O₂

化学文摘社编号:

796874-99-2

分子量:

339.43

UNSPSC Code:

12352200

PubChem Substance ID:

329825230

NACRES:

NA.77

MDL number:

MFCD22201003

Assay:

≥95% (HPLC)

Form:

oil

Quality level:

100

Storage condition:

desiccated

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属性

产品名称

KYP-2047, ≥95% (HPLC)

Quality Level

100

assay

≥95% (HPLC)

form

oil

storage condition

desiccated

color

white to light brown

storage temp.

2-8°C

SMILES string

O=C(CCCc1ccccc1)N2CCC[C@H]2C(=O)N3CCC[C@H]3C#N

InChI

1S/C20H25N3O2/c21-15-17-10-5-13-22(17)20(25)18-11-6-14-23(18)19(24)12-4-9-16-7-2-1-3-8-16/h1-3,7-8,17-18H,4-6,9-14H2/t17-,18-/m0/s1

InChI key

SPXFAUXQZWJGCJ-ROUUACIJSA-N

说明

Application

KYP-2047可用于脯氨酰内肽酶介导的细胞信号转导研究。

Biochem/physiol Actions

KYP-2047可清除神经细胞氧化应激诱导的α-突触核蛋白聚集体。 α-突触核蛋白是帕金森病中路易小体的主要成分，可引起神经元细胞死亡和痴呆。

KYP-2047是一种非常有效的选择性脯氨酰寡肽酶（POP）抑制剂，也被称为脯氨酰内肽酶（PEP或PE）。 Ki = 0.023 nM（猪）。

KYP-2047是一种非常有效的选择性脯氨酰寡肽酶（POP）抑制剂，也被称为脯氨酰内肽酶（PEP或PE）。Ki = 0.023nM（猪）。在体外已发现KYP-2047对谷氨酸和氧气、葡萄糖剥夺具有神经保护作用。它还被用来抑制AcSDKP从其前体43-mer胸腺素β4（Tβ4）的形成。Ac-SDKP可参与造血干细胞分化，具有促血管生成作用和抗纤维化作用。

Features and Benefits

该化合物是受体分类及信号转导手册上神经肽酶页面上的特色化合物。想要浏览手册的其他页面，请单击此处。

pictograms

GHS07

signalword

Warning

hcodes

H319

pcodes

P264 - P280 - P305 + P351 + P338 - P337 + P313

Hazard Classifications

Eye Irrit. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000289195

0000230086

0000150838

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