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SML0241

Ganirelix acetate salt

Name: Ganirelix acetate salt
Brand: SIGMA

≥95% (HPLC), lyophilized powder, GnRH antagonist

别名:

Antagon, N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N6-[bis(ethylamino)methylene]-D-lysyl-L-leucyl-N6-[bis(ethylamino)methylene]-L-lysyl-L-prolyl-D-alaninamide diacetate, Orgalutran

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关于此项目

经验公式（希尔记法）:

C₈₀H₁₁₃ClN₁₈O₁₃ · 2C₂H₄O₂

化学文摘社编号:

129311-55-3

分子量:

1690.42

UNSPSC Code:

51111800

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

lyophilized powder

Quality level:

100

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产品名称

Ganirelix acetate salt, ≥95% (HPLC)

Quality Level

100

assay

≥95% (HPLC)

form

lyophilized powder

color

white

storage temp.

−20°C

SMILES string

Clc1ccc(cc1)C[C@H](NC(=O)C(NC(=O)C)Cc5cc6c(cc5)cccc6)C(=O)N[C@@H](Cc4cnccc4)C(=O)N[C@H](CO)C(=O)N[C@H](Cc3ccc(cc3)O)C(=O)N[C@H](CCCCN=C(NCC)NCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN=C(NCC)NCC)C(=O)N2C(CCC2)C(=O)N[C@H](C)C(=O)N.OC(=O)C.OC(=O)C

InChI

1S/C80H113ClN18O13.2C2H4O2/c1-9-84-79(85-10-2)88-38-17-15-24-60(70(104)94-62(41-49(5)6)71(105)93-61(25-16-18-39-89-80(86-11-3)87-12-4)78(112)99-40-20-26-68(99)77(111)90-50(7)69(82)103)92-73(107)64(44-53-30-35-59(102)36-31-53)97-76(110)67(48-100)98-75(109)66(46-55-21-19-37-83-47-55)96-74(108)65(43-52-28-33-58(81)34-29-52)95-72(106)63(91-51(8)101)45-54-27-32-56-22-13-14-23-57(56)42-54;2*1-2(3)4/h13-14,19,21-23,27-37,42,47,49-50,60-68,100,102H,9-12,15-18,20,24-26,38-41,43-46,48H2,1-8H3,(H2,82,103)(H,90,111)(H,91,101)(H,92,107)(H,93,105)(H,94,104)(H,95,106)(H,96,108)(H,97,110)(H,98,109)(H2,84,85,88)(H2,86,87,89);2*1H3,(H,3,4)/t50-,60-,61+,62+,63?,64-,65+,66+,67-,68?;;/m1../s1

InChI key

OVBICQMTCPFEBS-HYVLHXRFSA-N

Biochem/physiol Actions

Ganirelix is a decapeptide GnRH antagonist.

Ganirelix is a decapeptide GnRH antagonist. Ganirelix acts by blocking the action of GnRH upon the pituitary, thus rapidly suppressing the production and action of LH and FSH.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

涉药品监管产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Follicular and endocrine profiles associated with different GnRH-antagonist regimens: a randomized controlled trial.

Juan Antonio García-Velasco et al.

Reproductive biomedicine online, 24(2), 153-162 (2011-12-27)

This trial assessed the impact of early initiation of gonadotrophin-releasing hormone (GnRH) antagonist on follicular and endocrine profiles compared with the fixed GnRH-antagonist protocol. Eighty-five oocyte donors were randomized to GnRH antagonist starting in the mid-luteal phase of the prestimulation

No association between endogenous LH and pregnancy in a GnRH antagonist protocol: part I, corifollitropin alfa.

Kevin J Doody et al.

Reproductive biomedicine online, 23(4), 449-456 (2011-08-23)

The relationship between endogenous LH concentrations and ongoing pregnancy rates among normogonadotrophic patients undergoing ovarian stimulation in a gonadotrophin-releasing hormone antagonist protocol were examined. In the Engage trial, 1506 patients received corifollitropin alfa (150 μg) or daily recombinant FSH (rFSH)

The relationship of premature progesterone rise with serum estradiol levels and number of follicles in GnRH antagonist/recombinant FSH-stimulated cycles.

D Kyrou et al.

European journal of obstetrics, gynecology, and reproductive biology, 162(2), 165-168 (2012-03-20)

To investigate the relationship between premature progesterone (P) rise and serum estradiol (E(2)) levels and the number of follicles in GnRH antagonist/rec-FSH stimulated cycles. Two hundred and seven patients treated by IVF/ICSI at the Centre for Reproductive Medicine of the

Predicting successful induction of oocyte maturation after gonadotropin-releasing hormone agonist (GnRHa) trigger.

N E Kummer et al.

Human reproduction (Oxford, England), 28(1), 152-159 (2012-10-19)

Are there factors predicting the number of total and mature oocytes retrieved after controlled ovarian hyperstimulation (COH) utilizing a gonadotropin-releasing hormone (GnRH) antagonist protocol and a GnRH agonist (GnRHa) to induce oocyte maturation? Peak estradiol (E₂) level, post-trigger LH and

Replacing GnRH agonists with GnRH antagonists in oocyte recipient cycle did not adversely affect the pregnancy rates.

Francisca Martínez et al.

European journal of obstetrics, gynecology, and reproductive biology, 159(2), 355-358 (2011-07-06)

The synchronization of the donor stimulation with the endometrial preparation of the recipient is usually done by downregulating the recipient's pituitary with a GnRH analog. The aim of this study is to compare pregnancy and implantation rates among premenopausal oocyte

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全球贸易项目编号

货号	GTIN
SML0241-5MG	04061833222294
SML0241-1MG	04061837077487

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