SML0246
Tirofiban hydrochloride monohydrate
≥98% (HPLC)
别名:
L 700462, MK 383, N-(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-L-tyrosine
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关于此项目
经验公式（希尔记法）:
C22H36N2O5S·HCl·H2O
化学文摘社编号:
分子量:
495.07
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D -10 to -18° (c=1, MeOH)
storage condition
desiccated
color
white to beige
solubility
DMSO: >12 mg/mL at warmed to 60 °C
shipped in
wet ice
storage temp.
−20°C
SMILES string
OC([C@@H](NS(CCCC)(=O)=O)CC1=CC=C(C=C1)OCCCCC2CCNCC2)=O.Cl.O
InChI
1S/C22H36N2O5S.ClH.H2O/c1-2-3-16-30(27,28)24-21(22(25)26)17-19-7-9-20(10-8-19)29-15-5-4-6-18-11-13-23-14-12-18;;/h7-10,18,21,23-24H,2-6,11-17H2,1H3,(H,25,26);1H;1H2/t21-;;/m0../s1
InChI key
HWAAPJPFZPHHBC-FGJQBABTSA-N
Gene Information
human ... ITGA2B(3674), ITGB3(3690)
Application
Tirofiban hydrochloride monohydrate has been used as an αIIbβ3 integrin (glycoprotein IIb/IIIa) inhibitor for mouse induced pluripotent stem cell (iPSC) culture.
Biochem/physiol Actions
Tirofiban might cause thrombocytopenia.
Tirofiban hydrochloride is a potent non-peptide, glycoprotein IIb/IIIa inhibitor. Blocks platelet aggregation and thrombus formation.
Tirofiban hydrochloride monohydrate is an αIIbβIII integrin inhibitor and an anticoagulant
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Yu-Lun Tseng et al.
Toxicology and applied pharmacology, 364, 106-113 (2018-12-29)
Collagen and convulxin induce platelet aggregation through glycoprotein VI (GPVI)-FcRγ-Syk signaling pathway. In addition, fibrinogen induces platelet activation through integrin αIIbβ3-FcγRIIa-Syk signaling pathway. We previously reported that high concentrations of selective serotonin reuptake inhibitors (SSRI) reduce platelet aggregation induced by
Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions (2015)
Xia Hong et al.
Journal of clinical laboratory analysis, 30(2), 108-113 (2014-11-27)
Activated clotting time (ACT) has been successfully applied during percutaneous coronary intervention (PCI) to monitor the extent of thrombin inhibition and anti-coagulation from unfractionated heparin (UFH) aiming to reduce the incidence of thrombotic adverse events and hemorrhagic complications. And this
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML0246-10MG | 04061837077623 |
| SML0246-50MG | 04061833222317 |