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Merck
CN

SML0247

利扎曲坦 苯甲酸盐

≥98% (HPLC)

别名:

MK-462, N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine benzoate salt

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关于此项目

经验公式（希尔记法）:
C15H19N5 · C7H6O2
化学文摘社编号:
145202-66-0
分子量:
391.47
NACRES:
NA.77
PubChem Substance ID:
329825257
UNSPSC Code:
12352200
MDL number:
MFCD00866224
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated

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产品名称

利扎曲坦 苯甲酸盐, ≥98% (HPLC)

InChI

1S/C15H19N5.C7H6O2/c1-19(2)6-5-13-8-17-15-4-3-12(7-14(13)15)9-20-11-16-10-18-20;8-7(9)6-4-2-1-3-5-6/h3-4,7-8,10-11,17H,5-6,9H2,1-2H3;1-5H,(H,8,9)

SMILES string

OC(=O)c1ccccc1.CN(C)CCc2c[nH]c3ccc(Cn4cncn4)cc23

InChI key

JPRXYLQNJJVCMZ-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: ≥5 mg/mL

storage temp.

room temp

Quality Level

100

Gene Information

human ... HTR1B(3351), HTR1D(3352)

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相关类别

Biochem/physiol Actions

Rizatriptan is a serotonin 5HT-1B/1D-receptor agonist used to treat migraine.
Rizatriptan is a serotonin 5HT-1B/1D-receptor agonist.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360

Hazard Classifications

Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
033M4734V
022M4725V

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Jeffrey L Seeburger et al.
Headache, 52(1), 57-67 (2011-11-15)
To assess efficacy and tolerability of rizatriptan orally disintegrating tablet (ODT) for treatment of acute migraine in patients using topiramate for migraine prophylaxis. There are limited data from prospective controlled trials demonstrating the benefit of triptans in patients who experience
Lidia Savi et al.
The journal of headache and pain, 12(6), 609-615 (2011-08-16)
The objectives of this study are to assess the efficacy and safety of frovatriptan, and rizatriptan in the subgroup of women with menstrually related migraine of a multicenter, randomized, double blind, cross-over study. Each patient received frovatriptan 2.5 mg or rizatriptan
Robert MacNeill et al.
Bioanalysis, 4(10), 1163-1173 (2012-06-02)
In the context of matrix effects in bioanalytical LC-MS/MS, a speculative link between free cholesterol, the recoveries of the compound from three common extraction procedures, and response enhancement was qualitatively investigated. Injections on-column of cholesterol both in solution and extracts
Anthony J Rodgers et al.
Headache, 51(3), 356-368 (2010-11-03)
To examine total migraine freedom (TMF), defined as pain freedom and absence of associated symptoms, using rizatriptan clinical trial data and to explore advantages of TMF as a single primary composite efficacy endpoint. The FDA has set a higher regulatory
Types of colitis based on histology.
Muhammed Sherid et al.
Disease-a-month : DM, 57(9), 457-489 (2011-09-29)
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