Name: Ivabradine hydrochloride
Brand: SIGMA

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About This Item

经验公式（希尔记法）:

C₂₇H₃₆N₂O₅ · HCl

CAS Number:

148849-67-6

分子量:

505.05

MDL编号:

MFCD00929899

UNSPSC代码:

12352200

PubChem化学物质编号:

329825289

NACRES:

NA.77

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Product Name

Ivabradine hydrochloride, ≥98% (HPLC)

质量水平

100

方案

≥98% (HPLC)

表单

powder

旋光性

[α]/D +5 to +9°, c = 1 in DMSO

储存条件

desiccated

颜色

white to beige

溶解性

H₂O: ≥5 mg/mL (warmed)

储存温度

2-8°C

SMILES字符串

Cl.COc1cc2CCN(CCCN(C)C[C@H]3Cc4cc(OC)c(OC)cc34)C(=O)Cc2cc1OC

InChI

1S/C27H36N2O5.ClH/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30;/h12-14,16,21H,6-11,15,17H2,1-5H3;1H/t21-;/m1./s1

InChI key

HLUKNZUABFFNQS-ZMBIFBSDSA-N

基因信息

human ... HCN4(10021)

应用

Ivabradine hydrochloride has been used as a potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel (HCN)2 blocker in embryoid body (EB) and rat engineered heart tissue (EHT).

Ivabradine hydrochloride has been used to investigate the effects of ivabradine on human primary chondrocytes (HPCs) to explore its potential in the treatment of osteoarthritis (OA).

生化/生理作用

Ivabradine hydrochloride is an open channel blocker of neuronal I(h) and related cardiac I(f) channels, which are comprised of subunits of the hyperpolarisation-activated cyclic nucleotide-gated (HCN) channels, in particular HCN4. Ivabradine has antianginal activity. It lowers heart rate and reduces myocardial oxygen demand.

Ivabradine hydrochloride is an open channel blocker of neuronal I(h) and related cardiac I(f) channels; HCN4 channel blocker; antianginal.

Ivabradine is used to treat chronic heart failure.

特点和优势

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Cyclic Nucleotide-Gated (CNG) and Hyperpolarization Activated Cyclic Nucleotide-Gated (HCN) Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.