SML0283
盐酸阿莫罗芬 盐酸盐
≥98% (HPLC), Ergosterol biosynthesis inhibitor, powder
别名:
(2R,6S)-rel-4-[3-[4-(1,1-Dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-morpholine hydrochloride, Ro 14-4767/002
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C21H35ON · HCl
化学文摘社编号:
分子量:
353.97
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
产品名称
盐酸阿莫罗芬 盐酸盐, ≥98% (HPLC)
SMILES string
Cl.CCC(C)(C)c1ccc(CC(C)CN2C[C@H](C)O[C@H](C)C2)cc1
InChI
1S/C21H35NO.ClH/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22;/h8-11,16-18H,7,12-15H2,1-6H3;1H/t16?,17-,18+;
InChI key
XZKWIPVTHGWDCF-KUZYQSSXSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: ≥5 mg/mL (warmed)
storage temp.
room temp
Quality Level
正在寻找类似产品? 访问 产品对比指南
Application
Amorolfine hydrochloride has been used as an antifungal agent.
Biochem/physiol Actions
Amorolfine blocks ergosterol biosynthesis by interfering with delta 14 reduction and the delta 7-8 isomerisation.
Amorolfine hydrochloride is a potential for treating onychomycosis infected nails by topical application. A 5% solution combination with fluconazole is effective on sensitive fungus in fingernail onychomycosis.
Amorolfine is a broad-based antifungal agent with fungicidal effects against most fungi, dermatophytes and yeasts.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Production of Trichophyton rubrum microspores in large quantities and its application to evaluate amorolfine/azole compound interactions in vitro
Laurent A and Monod M
Mycoses, 60(9), 581-586 (2017)
A randomized, double-blind study of amorolfine 5\% nail lacquer with oral fluconazole compared with oral fluconazole alone in the treatment of fingernail onychomycosis
Chandra S, et al.
Indian Journal of Dermatology, 64(4), 253-253 (2019)
Yuji Tabata et al.
Antimicrobial agents and chemotherapy, 60(2), 1035-1039 (2015-12-09)
Fungal nail infection (onychomycosis) is a prevalent disease in many areas of the world, with a high incidence approaching 23%. Available antifungals to treat the disease suffer from a number of disadvantages, necessitating the discovery of new efficacious and safe
Amorolfine
Haria M and BrysonHM
Drugs, 49(1), 103-120 (1995)
Sho Takahata et al.
Antimicrobial agents and chemotherapy, 60(2), 873-880 (2015-11-26)
Despite the existing treatment options for onychomycosis, there remains a strong demand for potent topical medications. ME1111 is a novel antifungal agent that is active against dermatophytes, has an excellent ability to penetrate human nails, and is being developed as
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持