SML0295
二氢杨梅素
≥98% (HPLC)
别名:
(2R,3R)-3,5,7-三羟基-2-（3,4,5-三羟基苯基）-2,3-二氢色-4-酮, 3,3′,4′,5,5′,7-六羟基黄烷酮, DHM, 蛇葡萄素
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关于此项目
经验公式（希尔记法）:
C15H12O8
化学文摘社编号:
分子量:
320.25
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C15H12O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,14-20,22H/t14-,15+/m0/s1
SMILES string
O=C1C2=C(O)C=C(O)C=C2O[C@H](C3=CC(O)=C(C(O)=C3)O)[C@H]1O
InChI key
KJXSIXMJHKAJOD-LSDHHAIUSA-N
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
white to beige
solubility
DMSO: ≥5 mg/mL (warmed)
storage temp.
−20°C
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General description
二氢杨梅素是显齿蛇葡萄中的主要类黄酮物质。
Application
二氢杨梅素已用于研究其对分化好的3T3-L1前脂肪细胞中的脂肪生成和葡萄糖摄取的影响。它还用于研究其抗肝癌细胞的抗肿瘤活性。
Biochem/physiol Actions
二氢杨梅素 (Ampelopsin) 是一种具有抗氧化和抗癌活性的黄烷醇。
二氢杨梅素 (Ampelopsin) 是一种具有抗氧化和抗癌活性的黄烷醇，具有抗酒精中毒作用。 它的抗酒精作用似乎是由于它在苯并二氮杂卓位点作为 GABA-A受体的正调节剂的作用。
二氢杨梅素具有抗炎作用。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Wei-Ming Zhou et al.
Molecules (Basel, Switzerland), 15(4), 2114-2123 (2010-04-30)
This study reports two novel 5-fluorouracil-substituted ampelopsin derivatives. The structures of two new derivatives were characterized by elemental analysis, 1H-NMR, 13C-NMR, IR and MS. Their anticancer activities in vitro against two cancer cell lines, K562 and K562/ADR, were investigated using
Yanjun Shi et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 87, 251-257 (2011-12-20)
The interaction between bovine serum albumin (BSA) and the anticancer drug molecule ampelopsin (AMP) was investigated using fluorescence spectroscopy, circular dichroism (CD) spectra, and time-resolved spectra under simulated physiological conditions. Fluorescence data showed that the intrinsic fluorescence of BSA was
Tiange Cai et al.
Biological & pharmaceutical bulletin, 34(9), 1501-1507 (2011-09-02)
Stilbenes are a class of compounds that has been reported to inhibit a variety of pathological processes during inflammatory reactions. In this study, cis-ampelopsin E, a stilbene isolated from the seeds of Paeonia suffruticosa, was shown to dose-dependently reduce the
Shimei Qi et al.
International immunopharmacology, 12(1), 278-287 (2011-12-24)
Ampelopsin (AMP), a plant flavonoid, has potent anti-inflammatory properties in vitro and in vivo. The molecular mechanisms of ampelopsin on pharmacological and biochemical actions of RAW264.7 macrophages in inflammation have not been clearly elucidated yet. In the present study, non-cytotoxic
Dihydromyricetin promotes hepatocellular carcinoma regression via a p53 activation-dependent mechanism
Zhang Q, et al.
Scientific Reports, 4, 4628-4628 (2014)
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