SML0307
普乐康尼
≥98% (HPLC), VP1 capsid protein binder, powder
别名:
3-[3,5-Dimethyl-4-[3-(3-methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole, VP 63843, Win 63843
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关于此项目
经验公式（希尔记法）:
C18H18F3N3O3
化学文摘社编号:
分子量:
381.35
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
普乐康尼, ≥98% (HPLC)
SMILES string
Cc1cc(CCCOc2c(C)cc(cc2C)-c3noc(n3)C(F)(F)F)on1
InChI
1S/C18H18F3N3O3/c1-10-7-13(16-22-17(27-24-16)18(19,20)21)8-11(2)15(10)25-6-4-5-14-9-12(3)23-26-14/h7-9H,4-6H2,1-3H3
InChI key
KQOXLKOJHVFTRN-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: ≥10 mg/mL (warmed)
storage temp.
room temp
Quality Level
General description
Pleconaril is a drug, that has antiviral activity.
Application
Pleconaril has been used as a control or reference compound to assess the antiviral activities of the benzothiophene and other heteroaromatic derivatives against hRV-B14, hRV-A21 and hRV-A71.
Biochem/physiol Actions
Pleconaril is an effective drug against enteroviral infections. It can be used to treat chronic meningoencephalitis caused by echo virus 6.This can block viral replication by blocking the viral uncoating process and viral attachment to host cell receptors.
Pleconaril is an orally bioavailable, broad-spectrum antipicorna-viral agent that binds to hydrophobic pocket in VP1 major capsid protein. Also, pleconaril delays the onset of diabetes in experimental animals infected with Ljungan virus (LV).
Pleconaril is an orally bioavailable, broad-spectrum antipicorna-viral agent.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Chronic 4
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Microscopic determination of drug solubility in plasma and calculation of injection rates with a plasma circulatory model to prevent precipitation on intravenous injection.
G A Portmann et al.
Journal of pharmaceutical and biomedical analysis, 13(9), 1189-1193 (1995-08-01)
Viral infections
Textbook of Clinical Neurology (Third Edition), 919-942 (2007)
A novel series of highly potent small molecule inhibitors of rhinovirus replication
Kim J, et al.
Journal of Medicinal Chemistry, 60(13), 5472-5492 (2017)
Chunlong Ma et al.
ACS infectious diseases, 6(8), 2260-2270 (2020-07-22)
Enterovirus D68 (EV-D68) is a re-emerging virus that causes moderate to severe respiratory diseases in children. In severe cases, EV-D68 infection can lead to neurological complications called acute flaccid myelitis (AFM). There is currently no antiviral or vaccine available for
Chronic meningoencephalitis caused by Echo virus 6 in a patient with common variable immunodeficiency
Radanovic I, et al.
Wiener Klinische Wochenschrift, 130(1-2), 70-72 (2018)
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