SML0309
苯基丁酸钠
≥98% (HPLC), histone deacetylase inhibitor, powder
别名:
4-PBA, 4-苯丁酸钠, 4-苯基丁酸, 4-苯基丁酸钠, 三酷酸酯, 苯丁酸钠制剂
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关于此项目
经验公式（希尔记法）:
C10H11NaO2
化学文摘社编号:
分子量:
186.18
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
苯基丁酸钠, ≥98% (HPLC)
SMILES string
[Na+].[O-]C(=O)CCCc1ccccc1
InChI key
VPZRWNZGLKXFOE-UHFFFAOYSA-M
InChI
1S/C10H12O2.Na/c11-10(12)8-4-7-9-5-2-1-3-6-9;/h1-3,5-6H,4,7-8H2,(H,11,12);/q;+1/p-1
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: ≥5 mg/mL
storage temp.
room temp
Quality Level
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Application
苯基丁酸钠用于作为内质网（ER）压力抑制物，用来研究ER压力在 betatrophin表达中的作用。
Biochem/physiol Actions
苯基丁酸钠是一种组蛋白去乙酰化酶抑制剂。
Features and Benefits
该化合物是基因调控研究的特色产品。点击此处以了解更多的基因调控特色产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问sigma.com/discover-bsm。
General description
苯基丁酸钠刺激尿中氮元素排出。它是一种前体药物，经过 β-氧化后形成乙酸苯酯。苯基丁酸钠用于处理尿素循环疾病。它可能和月经失调，闭经和食管和胃的疼痛性粘膜炎有关。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Association between betatrophin/ANGPTL8 and non-alcoholic fatty liver disease: animal and human studies
Lee YH, et al.
Scientific Reports, 6(3), 24013-24013 (2016)
Advances in Clinical Chemistry, Volume 17 (2014)
Phase 2 comparison of a novel ammonia scavenging agent with sodium phenylbutyrate in patients with urea cycle disorders: safety, pharmacokinetics and ammonia control
Lee B, et al.
Molecular Genetics and Metabolism, 100(3), 221-228 (2010)
The Molecular and Genetic Basis of Neurologic and Psychiatric Disease (2008)
Hilaire C Lam et al.
The Journal of clinical investigation, 123(12), 5212-5230 (2013-11-10)
Chronic obstructive pulmonary disease (COPD) involves aberrant airway inflammatory responses to cigarette smoke (CS) that are associated with epithelial cell dysfunction, cilia shortening, and mucociliary clearance disruption. Exposure to CS reduced cilia length and induced autophagy in vivo and in
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