SML0309
苯基丁酸钠
≥98% (HPLC), histone deacetylase inhibitor, powder
别名:
4-PBA, 4-苯丁酸钠, 4-苯基丁酸, 4-苯基丁酸钠, 三酷酸酯, 苯丁酸钠制剂
Product Name
苯基丁酸钠, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
H2O: ≥5 mg/mL
储存温度
room temp
SMILES字符串
[Na+].[O-]C(=O)CCCc1ccccc1
InChI
1S/C10H12O2.Na/c11-10(12)8-4-7-9-5-2-1-3-6-9;/h1-3,5-6H,4,7-8H2,(H,11,12);/q;+1/p-1
InChI key
VPZRWNZGLKXFOE-UHFFFAOYSA-M
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一般描述
苯基丁酸钠刺激尿中氮元素排出。它是一种前体药物，经过 β-氧化后形成乙酸苯酯。苯基丁酸钠用于处理尿素循环疾病。它可能和月经失调，闭经和食管和胃的疼痛性粘膜炎有关。
应用
苯基丁酸钠用于作为内质网（ER）压力抑制物，用来研究ER压力在 betatrophin表达中的作用。
生化/生理作用
苯基丁酸钠是一种组蛋白去乙酰化酶抑制剂。
特点和优势
该化合物是基因调控研究的特色产品。点击此处以了解更多的基因调控特色产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问sigma.com/discover-bsm。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Association between betatrophin/ANGPTL8 and non-alcoholic fatty liver disease: animal and human studies
Lee YH, et al.
Scientific Reports, 6(3), 24013-24013 (2016)
Phase 2 comparison of a novel ammonia scavenging agent with sodium phenylbutyrate in patients with urea cycle disorders: safety, pharmacokinetics and ammonia control
Lee B, et al.
Molecular Genetics and Metabolism, 100(3), 221-228 (2010)
The Molecular and Genetic Basis of Neurologic and Psychiatric Disease (2008)
Xiujing Dou et al.
Food & nutrition research, 62 (2018-12-24)
Host defense peptides (HDPs) possess direct antibacterial, antineoplastic, and immunomodulatory abilities, playing a vital role in innate immunity. Dietary-regulated HDP holds immense potential as a novel pathway for preventing infection. In this study, we examined the regulation mechanism of HDPs
Advances in Clinical Chemistry, Volume 17 (2014)
商品
We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.
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