SML0313
Pimelic Diphenylamide 106
≥98% (HPLC)
别名:
Compound 106, Inhibitor 106, N1-(2-Aminophenyl)-N7-(4-methylphenyl)-heptanediamide, RGFA 8, TC-H 106
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关于此项目
经验公式（希尔记法）:
C20H25N3O2
化学文摘社编号:
分子量:
339.43
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: ≥15 mg/mL
storage temp.
2-8°C
SMILES string
Cc1ccc(NC(=O)CCCCCC(=O)Nc2ccccc2N)cc1
InChI
1S/C20H25N3O2/c1-15-11-13-16(14-12-15)22-19(24)9-3-2-4-10-20(25)23-18-8-6-5-7-17(18)21/h5-8,11-14H,2-4,9-10,21H2,1H3,(H,22,24)(H,23,25)
InChI key
WTKBRPXPNAKVEQ-UHFFFAOYSA-N
Biochem/physiol Actions
Pimelic diphenylamides has the ability to enhance the expression of the frataxin gene in lymphocytes from Friedreich ataxia patients.
106 is a Class I HDAC inhibitor, demonstrating no activity against class II HDACs. It is a slow, tight-binding inhibitor of HDACs 1, 2, and 3, with a preference toward HDAC3 with Ki of 14 nM, 15 times lower than the Ki for HDAC1.
106 is a potent Class I HDAC inhibitor, demonstrating no activity against class II HDACs.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable