SML0315
CORM-A1
≥95% (NMR), CO donor, powder
别名:
硼烷碳酸钠
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关于此项目
经验公式（希尔记法）:
CH3BNa2O2
化学文摘社编号:
分子量:
103.82
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
CORM-A1, ≥95% (NMR)
SMILES string
[Na+].[Na+].[BH3-]C([O-])=O
InChI
1S/CH4BO2.2Na/c2-1(3)4;;/h2H3,(H,3,4);;/q-1;2*+1/p-1
InChI key
SOFPSQNQOQPAAJ-UHFFFAOYSA-M
assay
≥95% (NMR)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: >15 mg/mL
storage temp.
room temp
Quality Level
相关类别
Application
CORM-A1可用于：
- 提供一氧化碳（CO）并测试其在酵母和原代星形胶质细胞培养基中氧化应激时的细胞保护作用
- 作为小鼠巨噬细胞 J774A.1 中的 CO 供体，以测试其对细胞内啡呔升高的影响β
- 测试其对视网膜神经节细胞自噬激活的影响
Biochem/physiol Actions
CORM-A1是一种水溶性一氧化碳（CO）释放分子。
CORM-A1是一种水溶性一氧化碳（CO）释放分子，可用于研究CO对细胞系统的影响。一氧化碳（CO）是在血红素加氧酶降解血红素过程中产生的一种重要的气体信号调节因子。CORM-A1在哺乳动物细胞中具有抗氧化和抗炎作用。
它以 pH 值和随温度变化的方式介导 CO 的释放，进而缓解轻度血管舒张和低血压。在氧化应激过程中，CORM-A1 可在星形胶质细胞原代培养基中提供细胞保护。这种含硼的 CORM 可促进自噬作用。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Sara R Oliveira et al.
The European journal of neuroscience, 52(1), 2771-2780 (2020-03-14)
Previous studies about the modulation of the vasculature by CO were performed exclusively in male or sexually immature animals. Understanding the sex differences regarding systemic drug processing and pharmacodynamics is an important feature for safety assessment of drug dosing and
Helena Parfenova et al.
American journal of physiology. Heart and circulatory physiology, 315(4), H978-H988 (2018-07-22)
Neonatal asphyxia leads to cerebrovascular disease and neurological complications via a mechanism that may involve oxidative stress. Carbon monoxide (CO) is an antioxidant messenger produced via a heme oxygenase (HO)-catalyzed reaction. Cortical astrocytes are the major cells in the brain
Cláudia Figueiredo-Pereira et al.
FEMS yeast research, 19(5) (2019-07-26)
Autophagy is an autodigestive process, promoting cytoprotection by the elimination of dysfunctional organelles, misfolded proteins and toxic aggregates. Carbon monoxide (CO) is an endogenous gasotransmitter that under low concentrations prevents cell death and inflammation. For the first time, the role
Kapil K Upadhyay et al.
Redox biology, 28, 101314-101314 (2019-09-13)
Nuclear factor-erythroid 2 related factor 2 (Nrf2)-mediated signaling plays a central role in maintaining cellular redox homeostasis of hepatic cells. Carbon monoxide releasing molecule-A1 (CORM-A1) has been reported to stimulate up-regulation and nuclear translocation of Nrf2 in hepatocytes. However, the
Kapil K Upadhyay et al.
Toxicology and applied pharmacology, 360, 99-108 (2018-10-03)
Acute liver injury is frequently associated with oxidative stress. Here, we investigated the therapeutic potential of carbon monoxide releasing molecule A-1 (CORM A-1) in oxidative stress-mediated liver injury. Overnight-fasted mice were injected with acetaminophen (APAP; 300 mg/kg; intraperitoneally) and were sacrificed
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