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Merck
CN

SML0320

FR180204

≥98% (HPLC), ERK1 and ERK2 inhibitor, powder

别名:

5-(2-苯基-吡唑并[1,5-a]吡啶-3-基)-1H-吡唑并[3,4-c]哒嗪-3-基胺, 5-(2-苯基吡唑并[1,5-a]吡啶-3-基)-1H-吡唑并[3,4-c]吡啶并-3-胺, FR 180204

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关于此项目

经验公式（希尔记法）:
C18H13N7
化学文摘社编号:
865362-74-9
分子量:
327.34
UNSPSC Code:
12352200
PubChem Substance ID:
329825325
NACRES:
NA.77
MDL number:
MFCD14585805

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产品名称

FR180204, ≥98% (HPLC)

SMILES string

Nc1n[nH]c2nnc(cc12)-c3c(nn4ccccc34)-c5ccccc5

InChI

1S/C18H13N7/c19-17-12-10-13(20-22-18(12)23-21-17)15-14-8-4-5-9-25(14)24-16(15)11-6-2-1-3-7-11/h1-10H,(H3,19,21,22,23)

InChI key

XVECMUKVOMUNLE-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

faintly yellow to dark yellow

solubility

DMSO: ≥10 mg/mL

storage temp.

2-8°C

Quality Level

100

相关类别

Application

FR180204已被用作ERK抑制剂：
  • 用于阻断细胞外信号调节激酶 (ERK) 以确认同源框B7 (HOXB7) 是否通过 AKT/丝裂原活化蛋白激酶 (MAPK) 信号传导调节迁移和增生过程
  • 作为细胞外信号调节激酶 (ERK) 抑制剂用于研究信号通路抑制剂对分化和细胞牵引力的作用
  • 用于确定这种信号蛋白对于间充质基质细胞(MSC)治疗功效是不是必需的。

Biochem/physiol Actions

FR180204是一种有效的、选择性的、细胞可渗透的、具有ATP竞争性的ERK1和ERK2抑制剂。
FR180204是一种有效的细胞渗透性、ATP竞争性ERK1和ERK2抑制剂（促分裂原活化蛋白激酶（MAPK）/细胞外信号调节激酶（ERK）1/2）。
它可用于研究ERK的作用并用于药物开发。

Features and Benefits

《受体分类和信号转导》手册的 MAPK 页面有该化合物的介绍。如需浏览其他手册页面，请点击此处。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000391910
0000391911
0000302342
0000302342
0000391911

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Substrate stiffness and matrix composition coordinately control the differentiation of liver progenitor cells
Kourouklis AP, et al.
Biomaterials, 99, 82-94 (2016)
HOXB7 overexpression promotes cell proliferation and correlates with poor prognosis in gastric cancer patients by inducing expression of both AKT and MARKs
He X, et al.
Oncotarget, 8(1), 1247-1247 (2017)
Mario Sechi et al.
Scientific reports, 8(1), 15726-15726 (2018-10-26)
The anti-proliferative activity of dietary flavonoid fisetin has been validated in various cancer models. Establishing its precise mechanism of action has proved somewhat challenging given the multiplicity of its targets. We demonstrated that YB-1 promotes epithelial-to-mesenchymal transition and its inhibition
Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex
Ohori M, et al.
Biochemical and biophysical research communications, 336(1), 357-363 (2005)
Miho Tanaka et al.
Cancer research, 78(13), 3589-3603 (2018-04-25)
Natural killer (NK) cells express receptors specific for MHC class I (MHC-I) molecules involved in "missing-self" recognition of cancer and virus-infected cells. Here we elucidate the role of MHC-I-independent NKR-P1B:Clr-b interactions in the detection of oncogenic transformation by NK cells.
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商品

Mitogen-activated Protein Kinases (MAPKs)

The mitogen-activated protein kinase (MAPK) family consists of stress-activated (SAPK) and MAPKs. Learn about their network of signal transduction cascades that mediate cellular responses to a diverse range of stimuli.

丝裂原活化蛋白激酶(MAPK)

丝裂原活化蛋白激酶(MAPK)家族由应激激活(SAPK)和丝裂原活化(MAPK)的蛋白激酶组成。了解它们介导细胞多种刺激反应的信号转导级联网络。

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