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Merck
CN

SML0338

Lornoxicam

≥98% (HPLC)

别名:

6-Chloro-4-hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide, Chlortenoxicam, Ro 13-9297, TS 110

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关于此项目

经验公式(希尔记法):
C13H10ClN3O4S2
化学文摘社编号:
分子量:
371.82
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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质量水平

方案

≥98% (HPLC)

表单

powder

颜色

faintly yellow to dark yellow

溶解性

DMSO: >5 mg/mL (warmed)

储存温度

−20°C

SMILES字符串

CN1C(C(=O)Nc2ccccn2)=C(O)c3sc(Cl)cc3S1(=O)=O

InChI

1S/C13H10ClN3O4S2/c1-17-10(13(19)16-9-4-2-3-5-15-9)11(18)12-7(23(17,20)21)6-8(14)22-12/h2-6,18H,1H3,(H,15,16,19)

InChI key

WLHQHAUOOXYABV-UHFFFAOYSA-N

一般描述

Lornoxicam belongs to the oxicam class. It has anti-inflammatory and antipyretic properties. Lornoxicam prevents the synthesis of prostaglandin (PG) by inhibiting cyclo-oxygenase. It is used to relieve various types of symptoms associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute sciatica and low back pain.

应用

Lornoxicam has been used as a drug in melanin binding study with cassette dosing and rapid equilibrium dialysis inserts.

生化/生理作用

Lornoxicam is an oxicam-class NSAID with strong analgesic properties.
Lornoxicam is an oxicam-class NSAID; cyclooxygenase inhibitor.

象形图

Skull and crossbones

警示用语:

Danger

危险声明

危险分类

Acute Tox. 2 Oral

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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M Arslan et al.
Bratislavske lekarske listy, 113(4), 211-213 (2012-04-17)
Lornoxicam and iv paracetamol are commonly preferred to be used for postoperative analgesia. Although Aspirin is a well known non-steroid anti-inflammatory drug that decreases the erythrocyte deformability, there is no study comparing lornoxicam and iv paracetamol regarding their effects on
Jianjun Zhang et al.
Pakistan journal of pharmaceutical sciences, 25(2), 371-375 (2012-03-31)
A rapid, isocratic stability indicating high performance liquid chromatographic method was developed and validated for the estimation of lornoxicam in its powder for injection. The analysis was performed on a Shimadzu VP-ODS (4. 6 mm x 15 cm, 5 µm)
Susanne Schroeder et al.
Rheumatology international, 32(9), 2661-2667 (2011-07-27)
The local tolerability of lornoxicam (Xefo) after single and repeated intraarticular administration was assessed in the rabbit and compared to established standard therapies (hyaluronic acid--Synvisc and the glucocorticoid triamcinolone--Triam), and the results are discussed in the context of the literature.
Hany A Mowafi et al.
World journal of surgery, 36(9), 2039-2044 (2012-05-16)
The aim of this prospective, randomized, double-blind study was to determine the more effective supplemental analgesic, paracetamol or lornoxicam, for postoperative pain relief after lower abdominal surgery. Sixty patients scheduled for lower abdominal surgery under general anesthesia were randomly allocated
Mustafa Arslan et al.
Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology, 23(4), 160-166 (2012-02-01)
The purpose of the present study was to determine the efficacy of intravenous (iv) paracetamol and iv lornoxicam on postoperative analgesia and the reduction in tramadol consumption. Sixty patients (ASA class 1-2, age: 18-72 years) undergoing thyroidectomy were enrolled in

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