SML0341
Importazole
≥98% (HPLC), importin-β transport receptor inhibitor, powder
别名:
N-(1-Phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-amine
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关于此项目
经验公式（希尔记法）:
C20H22N4
化学文摘社编号:
分子量:
318.42
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
产品名称
Importazole, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: >5 mg/mL
storage temp.
2-8°C
SMILES string
CC(C1=CC=CC=C1)NC2=NC(N3CCCC3)=NC4=C2C=CC=C4
InChI
1S/C20H22N4/c1-15(16-9-3-2-4-10-16)21-19-17-11-5-6-12-18(17)22-20(23-19)24-13-7-8-14-24/h2-6,9-12,15H,7-8,13-14H2,1H3,(H,21,22,23)
InChI key
HKGJEZIGDHFJFL-UHFFFAOYSA-N
Application
Importazole has been used:
- to inhibit importin-β and to elucidate the mechanism of enhanced nuclear localization of heat shock protein 70 (HSP70) by vaccinia-related kinase 3 (VRK3)
- to treat COS?7 cells transfected with the expressing vectors of WT HNF4α , S78A, and S78D to study its effect
- as a KPNB inhibitor to determine whether CREB-regulated co-activator 1 (CRTC1) would be escorted into the nucleus by the classical nuclear localizing sequence (NLS)- dependent machinery
- as a functional inhibitor of Importin β in embryo treatment
- as an importin inhibitor to treat the transfected H1299 cells to block nuclear translocation of phosphorylated p53-RS
Biochem/physiol Actions
Importazole is an inhibitor of importin-β transport receptors.
Importazole is an inhibitor of importin-β transport receptors. During interphase, the transport receptor importin-β carries cargoes into the nucleus, where RanGTP releases them. Importazole somehow disrupts the importin/RAN interaction. Importazole is selective among other transporters. Compounds are imported into, but not out of, cells.
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable