AZD-7762 hydrochloride

Name: AZD-7762 hydrochloride
Brand: SIGMA

≥98% (HPLC)

别名:

5-(3-Fluorophenyl)-3-ureidothiophene-2-carboxylic acid N-[(S)-piperidin-3-yl]amide hydrochloride, AZD 7762 hydrochloride

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所有图片(1)

About This Item

经验公式（希尔记法）:

C₁₇H₁₉FN₄O₂S · HCl

CAS Number:

1246094-78-9

分子量:

398.88

MDL编号:

MFCD12546135

UNSPSC代码:

12352200

PubChem化学物质编号:

329825353

NACRES:

NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

储存条件

desiccated

颜色

white to light brown

溶解性

DMSO: 15 mg/mL, clear

储存温度

−20°C

SMILES字符串

Cl.NC(=O)Nc1cc(sc1C(=O)N[C@H]2CCCNC2)-c3cccc(F)c3

InChI

1S/C17H19FN4O2S.ClH/c18-11-4-1-3-10(7-11)14-8-13(22-17(19)24)15(25-14)16(23)21-12-5-2-6-20-9-12;/h1,3-4,7-8,12,20H,2,5-6,9H2,(H,21,23)(H3,19,22,24);1H/t12-;/m0./s1

InChI key

WFZBLOIXZRZEDG-YDALLXLXSA-N

应用

AZD-7762 hydrochloride has been used:

as a checkpoint kinase 1 and 2 (CHK1/2) inhibitor to study its effect on the efficiency of non-homologous end-joining (NHEJ) repair in breast cancer cell lines
as a CHK1 inhibitor to serve as a positive control for replication stress in the assessment of fork restart events
as a CHK1/2 inhibitor to study its effects on DNA lesions during mice zygote development