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Merck
CN

SML0360

Sigma-Aldrich

TAK-715

≥98% (HPLC)

别名:

N-(4-(2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl)-2-pyridyl)benzamide

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关于此项目

经验公式（希尔记法）:
C24H21N3OS
化学文摘社编号:
303162-79-0
分子量:
399.51
MDL编号:
MFCD17012805
UNSPSC代码:
12352200
PubChem化学物质编号:
329825362
NACRES:
NA.77

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质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

faintly yellow to dark yellow

溶解性

DMSO: >15 mg/mL

储存温度

2-8°C

SMILES字符串

CCc1nc(-c2cccc(C)c2)c(s1)-c3ccnc(NC(=O)c4ccccc4)c3

InChI

1S/C24H21N3OS/c1-3-21-27-22(18-11-7-8-16(2)14-18)23(29-21)19-12-13-25-20(15-19)26-24(28)17-9-5-4-6-10-17/h4-15H,3H2,1-2H3,(H,25,26,28)

InChI key

HEKAIDKUDLCBRU-UHFFFAOYSA-N

基因信息

human ... MAPK14(1432)

相关类别

生化/生理作用

TAK-715 is a dual p38 MAPK and CKId/e inhibitor; inhibitor of Wnt-3a-stimulated β-catenin signaling.
TAK-715 is a potent p38 inhibitor that also inhibits CKId/e (casein kinase Id/e), known activator of Wnt/β-catenin signaling.

特点和优势

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302,H319

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
052M4622V

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Acta crystallographica. Section D, Biological crystallography, 68(Pt 8), 1041-1050 (2012-08-08)
The p38α mitogen-activated protein kinase regulates the synthesis of pro-inflammatory cytokines in response to stimulation by a diverse set of stress signals. Various different chemotypes and clinical candidates that inhibit p38α function have been reported over the years. In this
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