SML0362
NPS2143 盐酸盐
≥98% (HPLC), Calcium-sensing receptor antagonist, powder
别名:
2-氯-6-[（2R）-3-[[1,1-二甲基-2-（2-萘基）乙基]氨基]-2-羟基丙氧基]-苄腈盐酸盐（1:1）, NPS-2143 盐酸盐, SB-262470-A 盐酸盐
登录查看公司和协议定价
选择尺寸
关于此项目
经验公式（希尔记法）:
C24H25ClN2O2 · HCl
化学文摘社编号:
分子量:
445.38
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
NPS2143 盐酸盐, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
旋光性
[α]20/D +20 to +24°, c = 1.0 in methanol
储存条件
desiccated
颜色
white to beige
溶解性
DMSO: >10 mg/mL
储存温度
2-8°C
SMILES字符串
Cl.CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc3cccc(Cl)c3C#N
InChI
1S/C24H25ClN2O2.ClH/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26;/h3-12,20,27-28H,13,15-16H2,1-2H3;1H/t20-;/m1./s1
InChI key
ZEBNDUQLNGYBNL-VEIFNGETSA-N
相关类别
应用
NPS2143盐酸盐已用于研究钙敏感受体的功能：
- 调节肠钙转运
- 调节肠钙吸收的局部负反馈
- 发育过程中的感觉运动决策。
生化/生理作用
NPS2143是一种选择性钙敏感受体（CaR）拮抗剂。
NPS2143是一种选择性钙敏感受体（CaR）拮抗剂。该化合物可阻断细胞质钙浓度的增加，IC50为43 nM，并在广泛的细胞外钙浓度范围内刺激牛甲状旁腺细胞分泌甲状旁腺激素（PTH）。
NPS2143是苯烷基胺钙化化合物，可用于治疗常染色体显性低钙血症。它可作为hERG（人类ether-a-go-go相关基因）通道、CYP2D6（细胞色素P450 2D6）和单胺转运蛋白的阻断剂。
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Novel activating mutations of the calcium-sensing receptor: the calcilytic NPS-2143 mitigates excessive signal transduction of mutant receptors
Letz S, et al.
The Journal of Clinical Endocrinology and Metabolism, 95(10), E229-E233 (2010)
Hyunji Cho et al.
International journal of molecular sciences, 22(1) (2021-01-06)
Near the bone remodeling compartments (BRC), extracellular calcium concentration (Ca2+o) is locally elevated and bone marrow stromal cells (BMSCs) close to the BRC can be exposed to high calcium concentration. The calcium-sensing receptor (CaSR) is known to play a key
Kate E Lines et al.
Journal of molecular endocrinology, 67(3), 83-94 (2021-07-06)
Corticotrophinomas represent 10% of all surgically removed pituitary adenomas, however, current treatment options are often not effective, and there is a need for improved pharmacological treatments. Recently, JQ1+, a bromodomain inhibitor that promotes gene transcription by binding acetylated histone residues
Progress in Medicinal Chemistry, 57 (2018)
Activation of calcium-sensing receptor by allosteric agonists cinacalcet and AC-265347 abolishes the 1, 25 (OH) 2D3-induced Ca2+ transport: Evidence that explains how the intestine prevents excessive Ca2+ absorption
Wongdee K, et al.
Archives of Biochemistry and Biophysics, 657, 15-22 (2018)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持