SML0362
NPS2143 盐酸盐
≥98% (HPLC), Calcium-sensing receptor antagonist, powder
别名:
2-氯-6-[（2R）-3-[[1,1-二甲基-2-（2-萘基）乙基]氨基]-2-羟基丙氧基]-苄腈盐酸盐（1:1）, NPS-2143 盐酸盐, SB-262470-A 盐酸盐
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关于此项目
经验公式（希尔记法）:
C24H25ClN2O2 · HCl
化学文摘社编号:
分子量:
445.38
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
NPS2143 盐酸盐, ≥98% (HPLC)
SMILES string
Cl.CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc3cccc(Cl)c3C#N
InChI
1S/C24H25ClN2O2.ClH/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26;/h3-12,20,27-28H,13,15-16H2,1-2H3;1H/t20-;/m1./s1
InChI key
ZEBNDUQLNGYBNL-VEIFNGETSA-N
assay
≥98% (HPLC)
form
powder
optical activity
[α]20/D +20 to +24°, c = 1.0 in methanol
storage condition
desiccated
color
white to beige
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
Quality Level
相关类别
Application
NPS2143盐酸盐已用于研究钙敏感受体的功能：
- 调节肠钙转运
- 调节肠钙吸收的局部负反馈
- 发育过程中的感觉运动决策。
Biochem/physiol Actions
NPS2143是一种选择性钙敏感受体（CaR）拮抗剂。
NPS2143是一种选择性钙敏感受体（CaR）拮抗剂。该化合物可阻断细胞质钙浓度的增加，IC50为43 nM，并在广泛的细胞外钙浓度范围内刺激牛甲状旁腺细胞分泌甲状旁腺激素（PTH）。
NPS2143是苯烷基胺钙化化合物，可用于治疗常染色体显性低钙血症。它可作为hERG（人类ether-a-go-go相关基因）通道、CYP2D6（细胞色素P450 2D6）和单胺转运蛋白的阻断剂。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Activation of calcium-sensing receptor by allosteric agonists cinacalcet and AC-265347 abolishes the 1, 25 (OH) 2D3-induced Ca2+ transport: Evidence that explains how the intestine prevents excessive Ca2+ absorption
Wongdee K, et al.
Archives of Biochemistry and Biophysics, 657, 15-22 (2018)
Hyunji Cho et al.
International journal of molecular sciences, 22(1) (2021-01-06)
Near the bone remodeling compartments (BRC), extracellular calcium concentration (Ca2+o) is locally elevated and bone marrow stromal cells (BMSCs) close to the BRC can be exposed to high calcium concentration. The calcium-sensing receptor (CaSR) is known to play a key
Kate E Lines et al.
Journal of molecular endocrinology, 67(3), 83-94 (2021-07-06)
Corticotrophinomas represent 10% of all surgically removed pituitary adenomas, however, current treatment options are often not effective, and there is a need for improved pharmacological treatments. Recently, JQ1+, a bromodomain inhibitor that promotes gene transcription by binding acetylated histone residues
Prolonged exposure to 1, 25 (OH) 2D3 and high ionized calcium induces FGF-23 production in intestinal epithelium-like Caco-2 monolayer: A local negative feedback for preventing excessive calcium transport
Rodrat M, et al.
Archives of Biochemistry and Biophysics, 640, 10-16 (2018)
Progress in Medicinal Chemistry, 57 (2018)
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