SML0364
RAD51抑制剂B02
≥98% (HPLC), RAD51 recombinase inhibitor, powder
别名:
3-（苯甲基）-2-[（1E）-2-（3-吡啶基）乙烯基]-4（3H）-喹唑啉酮
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关于此项目
经验公式（希尔记法）:
C22H17N3O
CAS Number:
分子量:
339.39
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
Product Name
RAD51抑制剂B02, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to dark brown
溶解性
DMSO: ≥5 mg/mL
储存温度
2-8°C
SMILES字符串
O=C1N(CC2=CC=CC=C2)C(/C=C/C3=CN=CC=C3)=NC4=C1C=CC=C4
InChI
1S/C22H17N3O/c26-22-19-10-4-5-11-20(19)24-21(13-12-17-9-6-14-23-15-17)25(22)16-18-7-2-1-3-8-18/h1-15H,16H2/b13-12+
InChI key
GEKDQXSPTHHANP-OUKQBFOZSA-N
相关类别
应用
RAD51 抑制剂B02已被用于：
- 测试其对猪卵母细胞极体排放（PBE）率的影响
- 用于猪胚胎的RAD51抑制
- 作为RAD51 抑制剂并用于测试其对诱导多能干细胞 (iPSC) 中靶向氨基酸替换 (TNS) 的影响
生化/生理作用
B02 (3-（苯甲基）-2-[（1E）-2-（3-吡啶基）乙烯基]-4（3H）-喹唑啉酮是一种吡啶基乙烯基喹唑啉酮化合物，可以穿透细胞。B02抑制人RAD51重组酶及之后核线的形成。它可以中止癌细胞中的同源重组（HR）修复活动。B02促进多发性骨髓瘤中的细胞凋亡，同时也是敏化多柔比星的关键。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
RAD51 maintains chromosome integrity and mitochondrial distribution during porcine oocyte maturation in vitro
Jin ZL and Kim NH
Journal of Reproduction and Development (2017)
Inhibition of DNA repair protein RAD51 affects porcine preimplantation embryo development
Jin ZL, et al.
Reproduction (Cambridge, England), 157(3) (2019)
Ivana Murfuni et al.
PLoS genetics, 9(10), e1003910-e1003910 (2013-11-10)
In checkpoint-deficient cells, DNA double-strand breaks (DSBs) are produced during replication by the structure-specific endonuclease MUS81. The mechanism underlying MUS81-dependent cleavage, and the effect on chromosome integrity and viability of checkpoint deficient cells is only partly understood, especially in human
A small-molecule inhibitor of RAD51 reduces homologous recombination and sensitizes multiple myeloma cells to doxorubicin
Alagpulinsa DA, et al.
Frontiers in Oncology, 4, 289-289 (2014)
Chengkun Wang et al.
Nucleic acids research, 49(6), e36-e36 (2021-02-24)
Several existing technologies enable short genomic alterations including generating indels and short nucleotide variants, however, engineering more significant genomic changes is more challenging due to reduced efficiency and precision. Here, we developed RecT Editor via Designer-Cas9-Initiated Targeting (REDIT), which leverages phage
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