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SML0370

岩白菜素

Name: 岩白菜素
Brand: SIGMA

≥98% (HPLC), runt-related transcription factor 1 (RUNX1) regulator, powder

别名:

2-[（联苯-4-基）氨甲酰基] 苯甲酸, 4′-苯基邻苯二甲酸 (8CI), KGN

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关于此项目

经验公式（希尔记法）:

C₂₀H₁₅NO₃

化学文摘社编号:

4727-31-5

分子量:

317.34

UNSPSC Code:

12352200

PubChem Substance ID:

329825371

NACRES:

NA.77

MDL number:

MFCD00560510

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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产品名称

岩白菜素, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

solubility

DMSO: >15 mg/mL

storage temp.

room temp

SMILES string

O=C(NC1=CC=C(C2=CC=CC=C2)C=C1)C(C=CC=C3)=C3C(O)=O

InChI

1S/C20H15NO3/c22-19(17-8-4-5-9-18(17)20(23)24)21-16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-13H,(H,21,22)(H,23,24)

InChI key

SLUINPGXGFUMLL-UHFFFAOYSA-N

Biochem/physiol Actions

Kartogenin是小杂环化合物。它参与Runt相关转录因子1(RUNX1)的调节，在软骨细胞增殖和存活中起重要作用。

Kartogenin 诱导多能间充质干细胞 (MSCs) 选择性分化为软骨细胞。

Kartogenin 诱导多能间充质干细胞 (MSCs) 选择性分化为软骨细胞。Kartogenin 与细丝蛋白 A 结合，破坏了细丝蛋白 A 和 CBFβ 之间的特异性相互作用（核心结合因子 β亚单位）。显然，kartogenin 通过调节 CBFβ 的核定位诱导软骨形成.

存储类别

11 - Combustible Solids

wgk

WGK 3

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000529379

0000529381

0000399536

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Effects of Grape Seed Extract and Proanthocyanidin B2 on In Vitro Proliferation, Viability, Steroidogenesis, Oxidative Stress, and Cell Signaling in Human Granulosa Cells.

Alix Barbe et al.

International journal of molecular sciences, 20(17) (2019-08-31)

Reactive oxygen species (ROS) which lead to oxidative stress affect ovarian function. Grape seed extract (GSE) could be proposed as an effective antioxidant, particularly due to its proanthocyanidin content. In this study, we investigated a dose effect (0, 0.01, 0.1

11-Ketotestosterone Is a Major Androgen Produced in Human Gonads.

Yoshitaka Imamichi et al.

The Journal of clinical endocrinology and metabolism, 101(10), 3582-3591 (2016-07-19)

11-ketotestosterone (11-KT) is a novel class of active androgen. However, the detail of its synthesis remains unknown for humans. The objective of this study was to clarify the production and properties of 11-KT in human. Design, Participants, and Methods: Expression

Kartogenin induces cartilage-like tissue formation in tendon-bone junction.

Jianying Zhang et al.

Bone research, 2 (2014-11-25)

Tendon-bone junctions (TBJs) are frequently injured, especially in athletic settings. Healing of TBJ injuries is slow and is often repaired with scar tissue formation that compromises normal function. This study explored the feasibility of using kartogenin (KGN), a biocompound, to

Diethylstilbestrol administration inhibits theca cell androgen and granulosa cell estrogen production in immature rat ovary.

Yoshitaka Imamichi et al.

Scientific reports, 7(1), 8374-8374 (2017-08-23)

Diethylstilbestrol (DES), a strong estrogenic compound, is well-known to affect the reproductive system. In this study, we investigated the effects of DES administration on gonadotropin levels and ovarian steroidogenesis in prepubertal rats. DES treatment acutely reduced serum LH levels, followed

Photo-Cross-Linked Scaffold with Kartogenin-Encapsulated Nanoparticles for Cartilage Regeneration.

Dongquan Shi et al.

ACS nano, 10(1), 1292-1299 (2016-01-13)

The regeneration of cartilage, an aneural and avascular tissue, is often compromised by its lack of innate abilities to mount a sufficient healing response. Kartogenin (KGN), a small molecular compound, can induce bone marrow-derived mesenchymal stem cells (BMSCs) into chondrocytes.

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全球贸易项目编号

货号	GTIN
SML0370-5MG	04061837084409
SML0370-25MG	04061832633404

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