SML0370
岩白菜素
≥98% (HPLC), runt-related transcription factor 1 (RUNX1) regulator, powder
别名:
2-[（联苯-4-基）氨甲酰基] 苯甲酸, 4′-苯基邻苯二甲酸 (8CI), KGN
产品名称
岩白菜素, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
溶解性
DMSO: >15 mg/mL
储存温度
room temp
SMILES字符串
O=C(NC1=CC=C(C2=CC=CC=C2)C=C1)C(C=CC=C3)=C3C(O)=O
InChI
1S/C20H15NO3/c22-19(17-8-4-5-9-18(17)20(23)24)21-16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-13H,(H,21,22)(H,23,24)
InChI key
SLUINPGXGFUMLL-UHFFFAOYSA-N
相关类别
生化/生理作用
Kartogenin 诱导多能间充质干细胞 (MSCs) 选择性分化为软骨细胞。
Kartogenin 诱导多能间充质干细胞 (MSCs) 选择性分化为软骨细胞。Kartogenin 与细丝蛋白 A 结合，破坏了细丝蛋白 A 和 CBFβ 之间的特异性相互作用（核心结合因子 β亚单位）。显然，kartogenin 通过调节 CBFβ 的核定位诱导软骨形成.
Kartogenin是小杂环化合物。它参与Runt相关转录因子1(RUNX1)的调节，在软骨细胞增殖和存活中起重要作用。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Yoshitaka Imamichi et al.
The Journal of clinical endocrinology and metabolism, 101(10), 3582-3591 (2016-07-19)
11-ketotestosterone (11-KT) is a novel class of active androgen. However, the detail of its synthesis remains unknown for humans. The objective of this study was to clarify the production and properties of 11-KT in human. Design, Participants, and Methods: Expression
Jun Zhao et al.
EBioMedicine, 36, 526-538 (2018-10-09)
Disordered folliculogenesis is a key feature of polycystic ovary syndrome (PCOS), but the underlying molecular mechanism remains unclear. Long non-coding RNA (lncRNA) expression in luteinized granulosa cells (hLGCs) derived from women with and without PCOS were analyzed using microarray and
Hanyong Jin et al.
PloS one, 11(7), e0159112-e0159112 (2016-07-16)
Anti-Müllerian hormone (AMH) is required for proper sexual differentiation by regulating the regression of the Müllerian ducts in males. Recent studies indicate that AMH could be an important factor for maintaining the ovarian reserve. However, the mechanisms of AMH regulation
Dongquan Shi et al.
ACS nano, 10(1), 1292-1299 (2016-01-13)
The regeneration of cartilage, an aneural and avascular tissue, is often compromised by its lack of innate abilities to mount a sufficient healing response. Kartogenin (KGN), a small molecular compound, can induce bone marrow-derived mesenchymal stem cells (BMSCs) into chondrocytes.
Hui Li et al.
Endocrinology, 159(4), 1644-1657 (2018-02-21)
Transforming growth factor-β (TGF-β) 1 plays a critical role in regulating follicular development, and its dysregulation has been shown to be involved in the pathogenesis of ovulation dysfunction. SNAIL is a well-known transcriptional repressor that mediates TGF-β1-induced cellular functions. Pentraxin
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