SML0371
MLR-1023
≥98% (HPLC), Lyn kinase activator, powder
别名:
5-(3-Methylphenoxy)- 2(1H)-pyrimidinone, CP 26154, NSC 314335, Tolimidone
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关于此项目
经验公式（希尔记法）:
C11H10N2O2
化学文摘社编号:
分子量:
202.21
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
产品名称
MLR-1023, ≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 15 mg/mL (clear solution)
storage temp.
room temp
SMILES string
Cc1cccc(OC2=CNC(=O)N=C2)c1
InChI
1S/C11H10N2O2/c1-8-3-2-4-9(5-8)15-10-6-12-11(14)13-7-10/h2-7H,1H3,(H,12,13,14)
InChI key
HJQILFPVRNHTIG-UHFFFAOYSA-N
Biochem/physiol Actions
MLR-1023 has a therapeutic potential to treat type 2 diabetes.
MLR-1023 is a potent, orally active, allosteric activator of the non-receptor Src-related Lyn kinase that produces lasting glucose lowering, reduces HbA1c levels, and preserves pancreatic β-cells in db/db mice. MLR-1023 increased insulin receptor sensitivity. MLR-1023 (Tolimidone) is antiulcer agent.
MLR-1023 is a potent, orally active, allosteric activator of the non-receptor Src-related Lyn kinase; insulin receptor-potentiating agent; antiulcer agent.
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the InsR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable