SML0374
U-104
≥98% (HPLC)
别名:
4-[[[(4-Fluorophenyl)amino]carbonyl]amino]-benzenesulfonamide, NSC 213841
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关于此项目
经验公式（希尔记法）:
C13H12FN3O3S
化学文摘社编号:
分子量:
309.32
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
U-104, ≥98% (HPLC)
InChI key
YJQZNWPYLCNRLP-UHFFFAOYSA-N
SMILES string
O=C(NC1=CC=C(S(N)(=O)=O)C=C1)NC2=CC=C(F)C=C2
InChI
1S/C13H12FN3O3S/c14-9-1-3-10(4-2-9)16-13(18)17-11-5-7-12(8-6-11)21(15,19)20/h1-8H,(H2,15,19,20)(H2,16,17,18)
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: >15 mg/mL
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
U-104 is a carbonic anhydrase IX (CAIX) inhibitor and a CAXII inhibitor.
U-104 is an inhibitor of CA IX that binds only to CA IX under hypoxic conditions in vivo. The binding results in significant inhibition of tumor growth and metastasis formation in both spontaneous and experimental models of metastasis. U-104 reduces the medium acidity by inhibiting the catalytic activity of the CA IX. It binds specifically only to hypoxic cells expressing CA IX.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Miglė Paškevičiūtė et al.
American journal of cancer research, 10(6), 1761-1769 (2020-07-10)
The aim of our study was to assess the influence of two carbonic anhydrase (CA) inhibitors (methazolamide (MTZ)) and U-104 on weakly basic anticancer drug doxorubicin (DOX) and pegylated liposomal doxorubicin (PLD) delivery into monolayer-cultured 4T1 murine breast cancer cells
Timothy A Dinh et al.
Cell reports, 31(2), 107509-107509 (2020-04-16)
Fibrolamellar carcinoma (FLC) is a rare, therapeutically intractable liver cancer that disproportionately affects youth. Although FLC tumors exhibit a distinct gene expression profile, the chromatin regulatory landscape and the genes most critical for tumor cell survival remain unclear. Here, we
Narongrit Thongon et al.
The journal of physiological sciences : JPS, 69(1), 129-141 (2018-07-23)
The mechanism of proton pump inhibitors (PPIs) suppressing intestinal Mg2+ uptake is unknown. The present study aimed to investigate the role of purinergic P2Y receptors in the regulation of Mg2+ absorption in normal and omeprazole-treated intestinal epithelium-like Caco-2 monolayers. Omeprazole
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