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SML0392

Dexpramipexole dihydrochloride

Name: Dexpramipexole dihydrochloride
Brand: SIGMA

≥98% (HPLC)

别名:

(R)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride // (R)-Pramipexole dihydrochloride, (R)-4,5,6,7-Tetrahydro-6-(propylamino)-benzothiazole-2-amine dihydrochloride, (R)-Pramipexole dihydrochloride, KNS 760704, R-(+)-Pramipexole dihydrochloride, RPPX, SND 919CL2X

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关于此项目

经验公式（希尔记法）:

C₁₀H₁₇N₃S · 2HCl

化学文摘社编号:

104632-27-1

分子量:

284.25

NACRES:

NA.77

PubChem Substance ID:

329825389

UNSPSC Code:

12352200

MDL number:

MFCD13186799

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

desiccated

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属性

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D 60 to 70°, c = 1 in methanol

storage condition

desiccated

color

white to beige

solubility

H₂O: >15 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

Cl.Cl.CCCN[C@@H]1CCc2nc(N)sc2C1

InChI

1S/C10H17N3S.2ClH/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;/h7,12H,2-6H2,1H3,(H2,11,13);2*1H/t7-;;/m1../s1

InChI key

QMNWXHSYPXQFSK-XCUBXKJBSA-N

说明

Biochem/physiol Actions

R-(+)-Pramipexole is a neuroprotective agent; weak non-ergoline dopamine agonist.

R-(+)-Pramipexole is a neuroprotective agent; weak non-ergoline dopamine agonist. R-(+)-Pramipexole has been found to have neuroprotective effects and is being investigated for treatment of ALS. It reduces mitochondrial reactive oxygen species (ROS) production, inhibits the activation of apoptotic pathways, and increase cell survival in response to a variety of neurotoxins and β-amyloid neurotoxicity. Compared to the S-(-) isomer, R-(+)-Pramipexole has much lower dopamine agonist activity.