SML0409
STF-083010
≥98% (HPLC)
别名:
N-[（2-羟基-1-萘基）亚甲基]-2-噻吩磺酰胺
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关于此项目
经验公式（希尔记法）:
C15H11NO3S2
化学文摘社编号:
分子量:
317.38
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
light yellow to yellow-green
solubility
DMSO: 5 mg/mL (clear solution)
storage temp.
−20°C
SMILES string
OC1=C(/C=N/S(C2=CC=CS2)(=O)=O)C3=C(C=CC=C3)C=C1
InChI
1S/C15H11NO3S2/c17-14-8-7-11-4-1-2-5-12(11)13(14)10-16-21(18,19)15-6-3-9-20-15/h1-10,17H/b16-10+
InChI key
TVIVJHZHPKNDAQ-MHWRWJLKSA-N
相关类别
Application
STF-083010 已被用于：
- 研究烟酰胺的潜在抗脂肪毒性作用，并阐明基本机制
- 作为IRE1a抑制剂研究其对NOS 2表达的作用并考察促炎基因在星形细胞中表达的基本机制
- 在棕榈酸盐暴露前一小时阻断内源性XBP1裂解从而考察肌醇需求酶 1α (IRE1α ) 激活是否与棕榈酸盐细胞毒性有关。
Biochem/physiol Actions
STF-083010是ER跨膜蛋白IRE1的有效抑制剂，其可介导未折叠的蛋白质反应。STF-083010可抑制IRE1内切核酸酶和mRNA剪接活性以响应内质网（ER）应激，但对IRE1的激酶活性没有影响。
STF-083010是IRE-1 mRNA剪接活性的有效抑制剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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In obesity, adipose tissue infiltrating macrophages acquire a unique pro-inflammatory polarization, thereby playing a key role in the development of chronic inflammation and Type 2 diabetes. Increased saturated fatty acids (SFAs) levels have been proposed to drive this specific polarization.
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML0409-25MG | 04061832824512 |
| SML0409-5MG | 04061837084478 |
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