SML0412
IM-54
≥98% (HPLC)
别名:
1-Methyl-3-(1-methyl-1H-indol-3-yl)-4-(pentylamino)-1H-pyrrole-2,5-dione, 2-(1H-Indol-3-yl)-3-pentylamino-maleimide
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C19H23N3O2
化学文摘社编号:
分子量:
325.40
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
light orange to dark orange
solubility
DMSO: 5 mg/mL (clear solution)
storage temp.
2-8°C
SMILES string
CCCCCNC1=C(C(=O)N(C)C1=O)c2cn(C)c3ccccc23
InChI
1S/C19H23N3O2/c1-4-5-8-11-20-17-16(18(23)22(3)19(17)24)14-12-21(2)15-10-7-6-9-13(14)15/h6-7,9-10,12,20H,4-5,8,11H2,1-3H3
InChI key
SGLOMINNEBLJFF-UHFFFAOYSA-N
Biochem/physiol Actions
IM-54 is a cell permeable, potent and selective inhibitor of necrosis.
IM-54 is a cell permeable, potent and selective inhibitor of necrosis. The compound inhibits necrosis induced by oxidative stress. IM-54 does not inhibit apoptosis induced by anticancer drugs.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Wen Sun et al.
Free radical biology & medicine, 108, 433-444 (2017-04-18)
Necroptosis is a form of programmed necrosis mediated by signaling complexes with receptor-interacting protein 1 (RIP1) and RIP3 kinases as the main mediators. However, the underlying execution pathways of this phenomenon have yet to be elucidated in detail. In this
Mladen Korbelik et al.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 19(9), 1145-1151 (2020-08-22)
Our recent investigation uncovered that the acid ceramidase inhibitor LCL521 enhances the direct tumor cell killing effect of photodynamic therapy (PDT) treatment. The present study aimed at elucidating the mechanisms underlying this effect. Exposing mouse squamous cell carcinoma SCCVII cells
Longhao Sun et al.
Autophagy, 13(4), 703-714 (2017-01-26)
Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive and lethal cancer. The role of autophagy in the pathobiology of PDAC is intricate, with opposing functions manifested in different cellular contexts. MIR506 functions as a tumor suppressor in many cancer types
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML0412-25MG | 04061833222706 |
| SML0412-5MG | 04061833222713 |