SML0414
NCX 4040
≥98% (HPLC)
别名:
2-(Acetyloxy)benzoic acid 4-(nitroxymethyl)phenyl ester, NO-aspirin
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关于此项目
经验公式（希尔记法）:
C16H13NO7
化学文摘社编号:
分子量:
331.28
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
protect from light
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
white to beige
solubility
DMSO: 15 mg/mL (clear solution)
storage temp.
−20°C
SMILES string
CC(=O)Oc1ccccc1C(=O)Oc2ccc(CO[N+]([O-])=O)cc2
InChI
1S/C16H13NO7/c1-11(18)23-15-5-3-2-4-14(15)16(19)24-13-8-6-12(7-9-13)10-22-17(20)21/h2-9H,10H2,1H3
InChI key
CTHNKWFUDCMLIQ-UHFFFAOYSA-N
Biochem/physiol Actions
NCX 4040 is a nitric oxide-donating form of aspirin.
NCX 4040 is a nitric oxide-donating form of aspirin. NCX 4040 inhibits cyclooxygenase activity and releases NO, which can down-regulate COX2 expression and reduce the levels of superoxide accumulation. In the human monocytic cell line THP1, the compound inhibits PGE2 production and cytokine expression, and appears to stabilize IkB by inhibiting proteasome function. NCX 4040 has been shown to induce apoptosis in several tumor cell lines.
Features and Benefits
This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Danger
hcodes
Hazard Classifications
Aquatic Acute 1 - Eye Dam. 1 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable