TCN-201

Name: TCN-201
Brand: SIGMA

≥98% (HPLC)

别名:

3-Chloro-4-fluoro-N-[(4-{[2-(phenylcarbonyl)hydrazino]carbonyl}phenyl)methyl]benzenesulfonamide

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所有图片(1)

About This Item

经验公式（希尔记法）:

C₂₁H₁₇ClFN₃O₄S

CAS Number:

852918-02-6

分子量:

461.89

MDL编号:

MFCD06683895

UNSPSC代码:

12352200

PubChem化学物质编号:

329825411

NACRES:

NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 5 mg/mL (clear solution)

储存温度

2-8°C

SMILES字符串

Fc1ccc(cc1Cl)S(=O)(=O)NCc2ccc(cc2)C(=O)NNC(=O)c3ccccc3

InChI

1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28)

InChI key

FYIBXBFDXNPBSF-UHFFFAOYSA-N

生化/生理作用

TCN-201 is a NR2A-selective NMDAreceptor antagonist 1.

TCN-201 is a sulphonamide derivative, that negatively modulates glycine binding to the GluN1 (glutamate receptor subunit) subunit of the receptor.

TCN-201 is the first NMDA receptor antagonist that is specific for NR2A-subunit containing receptors. The pIC₅₀ for NR2A NMDA receptors is 6.8. TCN-201has no effect on NR2B-containing receptors at concentrations up to 50 mM.

特点和优势

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.