SML0419
Ebselen Oxide
≥98% (HPLC)
别名:
1-Oxide-2-phenyl-1,2-benzisoselenazol-3(2H)-one, Ebselen selenoxide, NSC 639772
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关于此项目
经验公式（希尔记法）:
C13H9NO2Se
化学文摘社编号:
分子量:
290.18
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352119
MDL number:
产品名称
Ebselen Oxide, ≥98% (HPLC)
InChI
1S/C13H9NO2Se/c15-13-11-8-4-5-9-12(11)17(16)14(13)10-6-2-1-3-7-10/h1-9H
SMILES string
O=C1N(c2ccccc2)[Se](=O)c3ccccc13
InChI key
SBTLFLABILGUMK-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL (clear solution)
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Ebselen Oxide is an oxidative product of ebselen containing selenoxide group. Unlike ebselen, it lacks anti-oxidative property. Ebselen oxide may suppress human immunodeficiency virus-1 (HIV-1) replication by inhibiting HIV-1 capsid protein, similar to ebselen.
Ebselen oxide is a potent inhibitor of α-Methylacyl coenzyme A racemase (AMACR).
Ebselen oxide is a potent inhibitor of a-Methylacyl coenzyme A racemase (AMACR).
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Irrit. 2 - STOT RE 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Suzie Thenin-Houssier et al.
Antimicrobial agents and chemotherapy, 60(4), 2195-2208 (2016-01-27)
The human immunodeficiency virus type 1 (HIV-1) capsid plays crucial roles in HIV-1 replication and thus represents an excellent drug target. We developed a high-throughput screening method based on a time-resolved fluorescence resonance energy transfer (HTS-TR-FRET) assay, using the C-terminal
Yuren Wang et al.
Drug design, development and therapy, 11, 1369-1382 (2017-05-13)
Histone deacetylases (HDACs) are key regulators of gene expression in cells and have been investigated as important therapeutic targets for cancer and other diseases. Different subtypes of HDACs appear to play disparate roles in the cells and are associated with
Chien-Feng Li et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(23), 6141-6152 (2014-11-12)
Myxofibrosarcomas frequently display arm-level gains on 5p. We characterized the pathogenetic and therapeutic relevance of the α-methylacyl coenzyme A racemase (AMACR) at 5p13.3. AMACR mRNA expression in myxofibrosarcomas was analyzed using the public transcriptome and laser-microdissected sarcoma cells. We performed
Chien-Feng Li et al.
Oncotarget, 5(22), 11588-11603 (2014-12-05)
Non-random gains of chromosome 5p have been observed in clinically aggressive gastrointestinal stromal tumors, whereas the driving oncogenes on 5p remain to be characterized. We used an integrative genomic and functional approach to identify amplified oncogenes on 5p and to
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