SML0421
SB265610
≥98% (HPLC)
别名:
1-（2-溴苯基）-3-（4-氰基-1H-苯并[d][1,2,3]三唑-7-基）脲, N-（2-溴苯基）-N′-（7-氰基-1H-苯并三唑-4-基）脲, SB 265610
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关于此项目
经验公式（希尔记法）:
C14H9BrN6O
化学文摘社编号:
分子量:
357.16
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
产品名称
SB265610, ≥98% (HPLC)
InChI
1S/C14H9BrN6O/c15-9-3-1-2-4-10(9)17-14(22)18-11-6-5-8(7-16)12-13(11)20-21-19-12/h1-6H,(H2,17,18,22)(H,19,20,21)
SMILES string
Brc1ccccc1NC(=O)Nc2ccc(C#N)c3nn[nH]c23
InChI key
SEDUMQWZEOMXSO-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to light brown
solubility
DMSO: 15 mg/mL, clear
storage temp.
2-8°C
Quality Level
Application
SB265610已用于：
- 作为一种半胱氨酸-氨基酸-半胱氨酸（CXC）-趋化因子受体2（CXCR2）拮抗剂，研究其对趋化因子与G蛋白偶联受体（GPCR）结合的影响
- 作为一种CXC-趋化因子受体1（CXCR1）抑制剂，研究其对炎症细胞趋化因子趋化活性的影响
- 作为一种CXCR2拮抗剂，研究其对中性粒细胞向大鼠脑内迁移的影响
Biochem/physiol Actions
SB265610是一种强效、选择性CXCR2趋化因子受体拮抗剂。
SB265610是一种强效、选择性CXCR2趋化因子受体拮抗剂。 其Kd = 2.5 nM。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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PLoS pathogens, 11(3), e1004778-e1004778 (2015-03-26)
Helminth parasites can cause considerable damage when migrating through host tissues, thus making rapid tissue repair imperative to prevent bleeding and bacterial dissemination particularly during enteric infection. However, how protective type 2 responses targeted against these tissue-disruptive multicellular parasites might
François Binet et al.
Science (New York, N.Y.), 369(6506) (2020-08-21)
In developed countries, the leading causes of blindness such as diabetic retinopathy are characterized by disorganized vasculature that can become fibrotic. Although many such pathological vessels often naturally regress and spare sight-threatening complications, the underlying mechanisms remain unknown. Here, we
Zongmin Jiang et al.
Scientific reports, 7(1), 14510-14510 (2017-11-08)
Microenvironment (or niche)-providing chemokines regulate many important biological functions of tissue-specific stem cells. However, to what extent chemokines influence human pluripotent stem cells (hPSCs) is not yet completely understood. In this study, we applied protein array to screen chemokines found
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