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Merck
CN

SML0428

GSK690693

≥98% (HPLC)

别名:

4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol

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关于此项目

经验公式（希尔记法）:
C21H27N7O3
化学文摘社编号:
937174-76-0
分子量:
425.48
MDL编号:
MFCD14105605
UNSPSC代码:
12352200
PubChem化学物质编号:
329825423
NACRES:
NA.77

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质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 5 mg/mL (clear solution)

储存温度

2-8°C

SMILES字符串

CCn1c(nc2c(ncc(OC[C@H]3CCCNC3)c12)C#CC(C)(C)O)-c4nonc4N

InChI

1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1

InChI key

KGPGFQWBCSZGEL-ZDUSSCGKSA-N

基因信息

human ... AKT1(207), AKT2(208), AKT3(10000), PRKACA(5566), PRKACB(5567), PRKACG(5568), PRKCA(5578), PRKCB(5579), PRKCD(5580), PRKCE(5581), PRKCG(5582), PRKCH(5583), PRKCI(5584), PRKCQ(5588), PRKCZ(5590), PRKD1(5587), PRKD3(23683)

相关类别

应用

GSK690693 has been used in western blotting and immunoprecipitations.

生化/生理作用

4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol/GSK690693 is a protein kinase B/AKT inhibitor. GSK690693 can prevent growth and apoptosis in acute lymphoblastic leukemia cell lines.
GSK690693 is a potent pan-AKT kinase inhibitor.
GSK690693 is an ATP competitive, potent pan-AKT kinase inhibitor with IC50 values of 2, 13, and 9 nM against AKT1, 2, and 3, respectively.

特点和优势

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000169321
0000156240
0000169321
0000126486

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Michael K Kiessling et al.
PloS one, 11(1), e0147682-e0147682 (2016-01-29)
High-risk neuroblastoma remains lethal in about 50% of patients despite multimodal treatment. Recent attempts to identify molecular targets for specific therapies have shown that Neuroblastoma RAS (NRAS) is significantly mutated in a small number of patients. However, few inhibitors for
The IKK/NF-kappaB signaling pathway requires Morgana to drive breast cancer metastasis
Fusella F, et al.
Nature Communications, 8(1), 1636-1636 (2017)
Identification of 4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-
Heerding D A, et al.
Journal of medicinal chemistry, 51(18), 5663-5679 (2008)
N Panupinthu et al.
Oncogene, 33(22), 2846-2856 (2013-07-16)
The Y-box binding protein-1 (YB-1) transcription factor is associated with unfavorable clinical outcomes. However, the mechanisms underlying this association remain to be fully elucidated. We demonstrate that YB-1 phosphorylation, indicative of YB-1 activation, is a powerful marker of outcomes for
AKT inhibitor, GSK690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines
Levy D S, et al.
Blood, 113(8), 1723-1729 (2009)
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实验方案

PKB/Akt

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