SML0430
PR-619
≥95% (HPLC), deubiquitylating enzymes (DBUs) inhibitor, powder
别名:
2,6-二氨基-3,5-二硫氰基吡啶, 硫氰酸 C,C′-（2,6-二氨基-3,5-吡啶二基）酯；2,6-二氨基吡啶-3,5-双（硫氰酸酯）
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关于此项目
经验公式（希尔记法）:
C7H5N5S2
化学文摘社编号:
分子量:
223.28
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
PR-619, ≥95% (HPLC)
SMILES string
Nc1nc(N)c(SC#N)cc1SC#N
InChI
1S/C7H5N5S2/c8-2-13-4-1-5(14-3-9)7(11)12-6(4)10/h1H,(H4,10,11,12)
InChI key
ZXOBLNBVNROVLC-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL (clear solution)
storage temp.
−20°C
Quality Level
Application
PR-619已被用于：
- 作为裂解缓冲液的成分，以及用作去泛素化酶抑制剂用于处理来源于SILAC-标记Jurkat 细胞的蛋白质
- 作为去泛素化酶抑制剂用于研究其对腺相关病毒 (AAV) 转导的影响
- 用于泛素化检测用放射免疫沉淀测定缓冲液 (RIPA)
Biochem/physiol Actions
PR-619 是一种细胞可透过性广谱去泛素化酶（DBUs）抑制剂。PR-619 在不直接影响蛋白酶体活性的情况下，诱导细胞中多泛素化蛋白质的积聚。
PR-619 细胞可透过性广谱去泛素化酶（DBU）抑制剂；通用去泛素化酶（DUB）抑制剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
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Themis is a new component of the TCR signaling machinery that plays a critical role during T cell development. The positive selection of immature CD4
Tyler Bland et al.
Endocrinology, 160(8), 1982-1998 (2019-06-15)
Leptin has neurotrophic actions in the hippocampus to increase synapse formation and stimulate neuronal plasticity. Leptin also enhances cognition and has antidepressive and anxiolytic-like effects, two hippocampal-dependent behaviors. In contrast, mice lacking leptin or the long form of the leptin
Cytosolic iron-sulfur assembly is evolutionarily tuned by a cancer-amplified ubiquitin ligase
Weon JL, et sl.
Molecular Cell, 69(1), 113-125 (2018)
Large-scale identification of ubiquitination sites by mass spectrometry
Udeshi ND, et al.
Nature Protocols, 8(10), 1950-1950 (2013)
Yang Wang et al.
Animal reproduction science, 187, 64-73 (2017-10-17)
This study was undertaken to investigate the dynamics of protein ubiquitination in pig gametes and their micro-environments, as well as to explore the action of deubiquitinases (DUBs) in sperm-oocyte binding. Protein ubiquitination states were evaluated by in the ejaculated sperm
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