SML0430
PR-619
≥95% (HPLC), deubiquitylating enzymes (DBUs) inhibitor, powder
别名:
2,6-二氨基-3,5-二硫氰基吡啶, 硫氰酸 C,C′-（2,6-二氨基-3,5-吡啶二基）酯；2,6-二氨基吡啶-3,5-双（硫氰酸酯）
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关于此项目
经验公式（希尔记法）:
C7H5N5S2
化学文摘社编号:
分子量:
223.28
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
PR-619, ≥95% (HPLC)
SMILES string
Nc1nc(N)c(SC#N)cc1SC#N
InChI
1S/C7H5N5S2/c8-2-13-4-1-5(14-3-9)7(11)12-6(4)10/h1H,(H4,10,11,12)
InChI key
ZXOBLNBVNROVLC-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL (clear solution)
storage temp.
−20°C
Quality Level
Application
PR-619已被用于：
- 作为裂解缓冲液的成分，以及用作去泛素化酶抑制剂用于处理来源于SILAC-标记Jurkat 细胞的蛋白质
- 作为去泛素化酶抑制剂用于研究其对腺相关病毒 (AAV) 转导的影响
- 用于泛素化检测用放射免疫沉淀测定缓冲液 (RIPA)
Biochem/physiol Actions
PR-619 是一种细胞可透过性广谱去泛素化酶（DBUs）抑制剂。PR-619 在不直接影响蛋白酶体活性的情况下，诱导细胞中多泛素化蛋白质的积聚。
PR-619 细胞可透过性广谱去泛素化酶（DBU）抑制剂；通用去泛素化酶（DUB）抑制剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
Yang Wang et al.
Animal reproduction science, 187, 64-73 (2017-10-17)
This study was undertaken to investigate the dynamics of protein ubiquitination in pig gametes and their micro-environments, as well as to explore the action of deubiquitinases (DUBs) in sperm-oocyte binding. Protein ubiquitination states were evaluated by in the ejaculated sperm
Hirotaka Takahashi et al.
Biomedicines, 8(6) (2020-06-10)
Protein ubiquitinations play pivotal roles in many cellular processes, including homeostasis, responses to various stimulations, and progression of diseases. Deubiquitinating enzymes (DUBs) remove ubiquitin molecules from ubiquitinated proteins and cleave the polyubiquitin chain, thus negatively regulating numerous ubiquitin-dependent processes. Dysfunctions
Anne Garreau et al.
Journal of immunology (Baltimore, Md. : 1950), 199(8), 2758-2766 (2017-09-08)
Themis is a new component of the TCR signaling machinery that plays a critical role during T cell development. The positive selection of immature CD4
Large-scale identification of ubiquitination sites by mass spectrometry
Udeshi ND, et al.
Nature Protocols, 8(10), 1950-1950 (2013)
Tyler Bland et al.
Endocrinology, 160(8), 1982-1998 (2019-06-15)
Leptin has neurotrophic actions in the hippocampus to increase synapse formation and stimulate neuronal plasticity. Leptin also enhances cognition and has antidepressive and anxiolytic-like effects, two hippocampal-dependent behaviors. In contrast, mice lacking leptin or the long form of the leptin
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