SML0435
AF-DX 116
≥98% (HPLC)
别名:
11-[[2-[（二乙胺基）甲基]-1-哌啶基]乙酰基]-5,1 1-二氢-6-吡啶并[2,3-b][1,4]苯二氮卓-6-酮, Otenzepad
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关于此项目
经验公式（希尔记法）:
C24H31N5O2
化学文摘社编号:
分子量:
421.54
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
drug control
regulated under CDSA - not available from Sigma-Aldrich Canada
color
white to beige
solubility
DMSO: 5 mg/mL (clear solution; warmed)
storage temp.
room temp
SMILES string
CCN(CC)CC1CCCCN1CC(=O)N2c3ccccc3C(=O)Nc4cccnc24
InChI
1S/C24H31N5O2/c1-3-27(4-2)16-18-10-7-8-15-28(18)17-22(30)29-21-13-6-5-11-19(21)24(31)26-20-12-9-14-25-23(20)29/h5-6,9,11-14,18H,3-4,7-8,10,15-17H2,1-2H3,(H,26,31)
InChI key
UBRKDAVQCKZSPO-UHFFFAOYSA-N
Application
AF-DX 116 用作 M2 毒蕈碱受体（M2AChR）选择性拮抗剂，以研究 M2AChR 对年轻糖尿病大鼠齿状回基底和碳水化合物刺激长期增强（DG-LTP）的调节和海马细胞前神经生长因子（proNGF）分泌的影响。
Biochem/physiol Actions
AF-DX 116 可在反复冷应激诱导的低血压大鼠模型中升高血压和心率。因此，它可以治疗与迷走神经症型自主神经功能障碍相关的低血压。
AF-DX 116是一种选择性M2毒蕈碱乙酰胆碱受体拮抗剂。
Features and Benefits
该化合物在受体分类和信号转导手册的 乙酰胆碱受体（毒蕈碱） 页面上有详细描述。想要浏览手册的其他页面， 请单击此处。
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Máriton D Santos et al.
The Journal of pharmacology and experimental therapeutics, 304(1), 254-265 (2002-12-20)
This study was designed to investigate the effects of the cholinesterase inhibitors soman and pyridostigmine bromide (PB) on synaptic transmission in the CA1 field of rat hippocampal slices. Soman (1-100 nM, 10-15 min) decreased the amplitude of GABAergic postsynaptic currents
Makoto Ukai et al.
European journal of pharmacology, 492(2-3), 183-187 (2004-06-05)
The effects of anticholinergic drugs selective for muscarinic receptor subtypes on prepulse inhibition of acoustic startle response were determined in mice. The prepulse inhibition is associated with sensorimotor information processing in the brain. The anticholinergic agent scopolamine (0.3 mg/kg, s.c.)
Leticia Ramírez-Lugo et al.
Neurobiology of learning and memory, 79(2), 184-193 (2003-02-20)
A number of studies have implicated cholinergic activity in the mediation of learning and memory processes. However, the specific role of muscarinic receptors in memory formation mechanisms is less known. The aim of the present study is to evaluate the
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML0435-25MG | 04061832075730 |
| SML0435-5MG | 04061837084539 |