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Merck
CN

SML0437

氧雄龙

≥98% (HPLC)

别名:

17β-羟基-17α-甲基-2-氧杂-5α--雄烷-3-酮, 8075CB, NSC 67068, SC 11585, 奥克西伦, 氧甲氢龙

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关于此项目

经验公式(希尔记法):
C19H30O3
化学文摘社编号:
分子量:
306.44
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
EC Number:
200-172-9
MDL number:
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InChI key

QSLJIVKCVHQPLV-PEMPUTJUSA-N

InChI

1S/C19H30O3/c1-17-11-22-16(20)10-12(17)4-5-13-14(17)6-8-18(2)15(13)7-9-19(18,3)21/h12-15,21H,4-11H2,1-3H3/t12-,13+,14-,15-,17-,18-,19-/m0/s1

SMILES string

C[C@]1(O)CC[C@H]2[C@@H]3CC[C@H]4CC(=O)OC[C@]4(C)[C@H]3CC[C@]12C

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -19 to -26°, c = 1 (CDCl3)

drug control

USDEA Schedule IIIN; regulated under CDSA - not available from Sigma-Aldrich Canada

color

white to beige

solubility

DMSO: 2 mg/mL (clear solution; warmed)

storage temp.

2-8°C

Quality Level

Gene Information

human ... AR(367)

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Biochem/physiol Actions

氧甲氢龙是一种合成代谢类固醇。
氧甲氢龙是一种合成合成代谢类固醇。它是一种非芳香化雄激素,无雌激素样作用,具有轻度雄激素样活性。氧甲氢龙的临床应用包括促进大范围手术或慢性感染或创伤后体重减轻后的体重增加,抵消与长期管理皮质类固醇相关的蛋白质分解代谢,缓解经常伴随骨质疏松的骨痛,治疗女孩的特纳综合征。

Features and Benefits

该化合物是受体分类及信号转导手册上核受体(类固醇)页面上的特色化合物。想要浏览手册的其他页面, 请单击此处

pictograms

Health hazard

signalword

Danger

Hazard Classifications

Carc. 2 - Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number

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Rhonda Orr et al.
Drugs, 64(7), 725-750 (2004-03-18)
There has been increasing interest in the development of effective agents that can be safely used to promote anabolism in the clinical setting for patients with chronic wasting conditions as well as in the prevention and treatment of frailty associated
Susan R Rose et al.
Pediatric blood & cancer, 61(1), 11-19 (2013-09-11)
A majority of Fanconi anemia (FA) patients will experience bone marrow failure (BMF) and androgen therapy (most often oxymetholone) may be utilized as a treatment to improve BMF-related cytopenias. However, oxymetholone is associated with toxicities making identification of other agents
Emma Jane Gault et al.
BMJ (Clinical research ed.), 342, d1980-d1980 (2011-04-16)
To examine the effect of oxandrolone and the timing of pubertal induction on final height in girls with Turner's syndrome receiving a standard dose of growth hormone. Randomised, double blind, placebo controlled trial. Setting 36 paediatric endocrinology departments in UK
Leonie A Menke et al.
Hormone research in paediatrics, 75(2), 115-122 (2010-09-04)
The weak androgen oxandrolone (Ox) may increase height but may also affect glucose metabolism in girls with Turner syndrome (TS). In a randomized, placebo-controlled, double-blind study, we assessed the effect of Ox at a dosage of either 0.06 or 0.03
Yesenia Rojas et al.
Expert opinion on pharmacotherapy, 13(17), 2485-2494 (2012-11-06)
The worldwide occurrence of burn injuries remains high despite efforts to reduce injury incidence through public awareness campaigns and improvements in living conditions. In 2004, almost 11 million people experienced burns severe enough to warrant medical treatment. Advances over the

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