SML0439
MBCQ
≥98% (HPLC)
别名:
4-((3,4-Methylenedioxybenzyl)amino)-6-chloroquinazoline
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关于此项目
经验公式（希尔记法）:
C16H12ClN3O2
化学文摘社编号:
分子量:
313.74
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
InChI
1S/C16H12ClN3O2/c17-11-2-3-13-12(6-11)16(20-8-19-13)18-7-10-1-4-14-15(5-10)22-9-21-14/h1-6,8H,7,9H2,(H,18,19,20)
SMILES string
Clc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
InChI key
CNODHOSDWZLJGA-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL (clear solution)
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
MBCQ is selective inhibitor of cGMP-specific phosphodiesterase PDE V.
MBCQ is selective inhibitor of cGMP-specific phosphodiesterase PDE V; IC50=19 nM.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Masashi Mukohda et al.
The Journal of clinical investigation, 129(6), 2318-2332 (2019-03-22)
Mice selectively expressing PPARγ dominant negative mutation in vascular smooth muscle exhibit RhoBTB1-deficiency and hypertension. Our rationale was to employ genetic complementation to uncover the mechanism of action of RhoBTB1 in vascular smooth muscle. Inducible smooth muscle-specific restoration of RhoBTB1
J F Heneghan et al.
American journal of physiology. Cell physiology, 309(5), C332-C347 (2015-06-26)
The potent trypanolytic properties of human apolipoprotein L1 (APOL1) can be neutralized by the trypanosome variant surface antigen gene product known as serum resistance-associated protein. However, two common APOL1 haplotypes present uniquely in individuals of West African ancestry each encode
商品
Cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and/or cGMP. There are 11 different mammalian PDE families.
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
环核苷酸磷酸二酯酶 (PDEs) 催化 cAMP 和/或 cGMP 的水解。存在有11种不同的哺乳动物PDE家族。
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