SML0443
SU-5402
≥98% (HPLC), powder, FGFR inhibitor
别名:
3-[4-甲基-2-（2-氧代-1,2-二氢-吲哚-3-亚甲基）-1H-吡咯-3-基]-丙酸, PF-02969207, PNU-029098
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C17H16N2O3
化学文摘社编号:
分子量:
296.32
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
SU-5402, ≥98% (HPLC)
SMILES string
Cc1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1CCC(O)=O
InChI
1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-
InChI key
JNDVEAXZWJIOKB-JYRVWZFOSA-N
assay
≥98% (HPLC)
form
powder
color
light yellow to dark orange
solubility
DMSO: 10 mg/mL (clear solution)
storage temp.
−20°C
Quality Level
Application
SU5402 已被用作成纤维细胞生长因子受体抑制剂：
- 在细胞信号传导实验中刺激细胞，用于 MTT（3-（4,5-二甲基噻唑-2-基）-2,5-二苯基四氮唑溴盐）试验
- ，以研究其对成骨标记物表达以及骨保护素和 RANKL（runt 相关转录因子 (RUNX)-2
- ）表达的影响，以制备细胞培养基用 DMSO（二甲基超氧化物）的储备液，并对胚胎进行共处理
- ，以研究其对成骨标记物的影响。
Biochem/physiol Actions
SU-5402 对酪氨酸激酶的活动具有抑制作用。与成纤维细胞生长因子受体 (FGFR) 上的 ATP 结合站点竞争性结合。
SU-5402 是一种 FGFR 拮抗剂和血管生成抑制剂。
SU-5402 是一种 FGFR 拮抗剂；血管生成抑制剂。
Features and Benefits
该化合物是激酶磷酸酶生物学研究的特色产品。 点击此处 ，发现更多特色激酶磷酸酶生物学产品。前往 sigma.com/discover-bsm了解更多关于其他研究领域的生物活性小分子。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
BMP2/Smad signaling pathway is involved in the inhibition function of fibroblast growth factor 21 on vascular calcification
Liu X, et al.
Biochemical and Biophysical Research Communications, 503, 930-937 (2018)
Fibroblast growth factor 21 plays an inhibitory role in vascular calcification in vitro through OPG/RANKL system
Cao F, et al.
Biochemical and Biophysical Research Communications, 491(3), 578-586 (2017)
Fibroblast growth factor (FGF)-23 inhibits renal phosphate reabsorption by activation of the mitogen-activated protein kinase pathway
Yamashita T, et al.
The Journal of Biological Chemistry, 277(31), 28265-28270 (2002)
Fang Liang et al.
Scientific reports, 5, 14468-14468 (2015-10-09)
Natural products are a rich resource for the discovery of therapeutic substances. By directly using 504 fine fractions from isolated traditional Chinese medicine plants, we performed a transgenic zebrafish based screen for anti-angiogenesis substances. One fraction, DYVE-D3, was found to
Existence of muscarinic acetylcholine receptor (mAChR) and fibroblast growth factor receptor (FGFR) heteroreceptor complexes and their enhancement of neurite outgrowth in neural hippocampal cultures
Di LV, et al.
Biochim. Biophys. Acta Gen. Subj., 1861(2), 235-245 (2017)
商品
Discover Bioactive Small Molecules for Kinase Phosphatase Biology
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持