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Merck
CN

SML0445

克立马丁 富马酸盐

≥98% (HPLC), antihistamine H1-antagonist, powder

别名:

(+)-2-[2-[(p-Chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methylpyrrolidine fumarate salt, (2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine fumarate salt, 1-Methyl-2-[2-(α-methyl-p-chlorobenzhydryloxy)ethyl]pyrrolidine fumarate salt, 1-Methyl-2-[2-(methyl-p-chlorodiphenylmethyloxy)ethyl]pyrrolidine fumarate salt, Meclastine fumarate salt, Mecloprodine

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关于此项目

经验公式（希尔记法）:
C21H26ClNO · C4H4O4
化学文摘社编号:
14976-57-9
分子量:
459.96
EC 号:
239-055-2
MDL编号:
MFCD00137486
UNSPSC代码:
12352200
PubChem化学物质编号:
329824727
NACRES:
NA.77

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产品名称

克立马丁 富马酸盐, ≥98% (HPLC)

质量水平

100

方案

≥98% (HPLC)

表单

powder

旋光性

[α]/D +15 to +25°, c = 1 in methanol

储存条件

desiccated

颜色

white to beige

溶解性

DMSO: 5 mg/mL (clear solution; warmed)

储存温度

room temp

SMILES字符串

OC(=O)\C=C\C(O)=O.CN1CCC[C@@H]1CCO[C@](C)(c2ccccc2)c3ccc(Cl)cc3

InChI

1S/C21H26ClNO.C4H4O4/c1-21(17-7-4-3-5-8-17,18-10-12-19(22)13-11-18)24-16-14-20-9-6-15-23(20)2;5-3(6)1-2-4(7)8/h3-5,7-8,10-13,20H,6,9,14-16H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t20-,21-;/m1./s1

InChI key

PMGQWSIVQFOFOQ-YKVZVUFRSA-N

基因信息

human ... HRH1(3269)

相关类别

一般描述

Clemastine fumarate is used to treat multiple sclerosis, sneezing and rhinorrhea linked to common cold. It stimulates oligodendrocyte progenitor cell (OPC) differentiation and myelination.

应用

Clemastine fumarate salt has been used as a stimulator of rodent oligodendrocyte generation and myelination in vitro and in vivo.

生化/生理作用

Clemastine fumarate is an antihistamine H1-antagonist and anticholinergic that also has antipruritic activity.
Clemastine fumarate is an antihistamine H1-antagonist and anticholinergic.

特点和优势

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000440006
0000440006
0000420612
0000420612
0000235019

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Vanessa E Hogan et al.
Annals of the rheumatic diseases, 71(11), 1888-1894 (2012-06-28)
Personalised healthcare is contingent on the identification of biomarkers that represent disease relevant pathways and predict drug response. The authors aimed to develop a gene expression signature in synovial tissue that could enrich clinical response of rheumatoid arthritis (RA) patients
Effectiveness of clemastine fumarate for treatment of rhinorrhea and sneezing associated with the common cold
Turner RB, et al.
Clinical Infectious Diseases, 25(4), 824-830 (1997)
Annica Tevell Aberg et al.
Rapid communications in mass spectrometry : RCM, 24(10), 1447-1456 (2010-04-23)
Cunninghamella elegans is a filamentous fungus that has been shown to biotransform drugs into the same metabolites as mammals. In this paper we describe the use of C. elegans to aid the identification of clemastine metabolites since high concentrations of
Murat Bas et al.
Annals of emergency medicine, 56(3), 278-282 (2010-05-08)
The pathophysiology of angiotensin-converting enzyme inhibitor (ACEi)-induced angioedema most likely resembles that of hereditary angioedema, ie, it is mainly mediated by bradykinin-induced activation of vascular bradykinin B2 receptors. We hypothesize that the bradykinin B2 receptor antagonist icatibant might be an
Induction of myelinating oligodendrocytes in human cortical spheroids
Madhavan M, et al.
Nature Methods, 15(9), 700-700 (2018)
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