SML0450
5-BDBD
≥98% (HPLC), P2X4 inhibitor, powder
别名:
5-（3-溴苯基）-1,3-二氢-2H-苯并呋喃并[3,2-E] -1,4-二氮杂-2-酮
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关于此项目
经验公式（希尔记法）:
C17H11BrN2O2
化学文摘社编号:
分子量:
355.19
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
5-BDBD, ≥98% (HPLC)
SMILES string
Brc1cccc(c1)C2=NCC(=O)Nc3c2oc4ccccc34
InChI key
NKYMVQPXXTZHSF-UHFFFAOYSA-N
InChI
1S/C17H11BrN2O2/c18-11-5-3-4-10(8-11)15-17-16(20-14(21)9-19-15)12-6-1-2-7-13(12)22-17/h1-8H,9H2,(H,20,21)
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 15 mg/mL (clear solution)
storage temp.
2-8°C
Quality Level
相关类别
Biochem/physiol Actions
5-BDBD 是 P2X4 的特异性抑制剂。
5-BDBD 是 P2X4 的特异性抑制剂。该化合物抑制 CHO 细胞中的 P2X4 电流，IC50 为 500nM。
在天然组织中，5-BDBD被认为是分析P2X受体（P2XRs）亚型P2X4R作用的有益拮抗剂。
Features and Benefits
该化合物的相关信息整理于受体分类和信号转导手册的 P2受体：P2X离子通道家族 页面。欲浏览其他手册页面，请 点击这里。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Ting Long et al.
Journal of neuroinflammation, 15(1), 245-245 (2018-09-01)
The mechanism underlying migraine chronification remains unclear. Central sensitization may account for this progression. The microglia P2X4 receptor (P2X4R) plays a pivotal role in the central sensitization of inflammatory and neuropathic pain, but there is no information about P2X4R in
Hyuck Joon Kwon et al.
Scientific reports, 6, 39302-39302 (2016-12-23)
Electrical stimulation (ES) is known to guide the development and regeneration of many tissues. However, although preclinical and clinical studies have demonstrated superior effects of ES on cartilage repair, the effects of ES on chondrogenesis remain elusive. Since mesenchyme stem
Claudio Coddou et al.
Neuroscience letters, 690, 219-224 (2018-10-27)
P2X receptors (P2XRs) are a family of ATP-gated ionic channels that are expressed in numerous excitable and non-excitable cells. Despite the great advance on the structure and function of these receptors in the last decades, there is still lack of
Yun-Ming Tu et al.
Food & function, 8(12), 4336-4346 (2017-09-25)
Circulating levels of free fatty acids (FFAs) are often found to be increased in patients with type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS). High plasma FFA levels may give rise to maladaptive macrophage activation and promote inflammatory responses
Bing Hu et al.
Iranian journal of basic medical sciences, 21(4), 364-369 (2018-05-26)
P2X4R is expressed in immunocyte and lung tissues. It has been a focus in inflammatory responses recently. This study investigated whether blockage of P2X4R attenuates allergic inflammation by modulating T cell response in ovalbumin-sensitized mice. Ovalbumin was used to sensitize
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