SML0466
LCS-1
≥98% (HPLC)
别名:
4,5-二氯-2-(3-甲基苯基)-3(2H)-哒嗪酮
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关于此项目
经验公式（希尔记法）:
C11H8Cl2N2O
化学文摘社编号:
分子量:
255.10
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
LCS-1, ≥98% (HPLC)
InChI
1S/C11H8Cl2N2O/c1-7-3-2-4-8(5-7)15-11(16)10(13)9(12)6-14-15/h2-6H,1H3
SMILES string
O=C1C(Cl)=C(Cl)C=NN1C2=CC=CC(C)=C2
InChI key
SYUPLLHVMCLXEM-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL (clear solutikon, warmed)
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
LCS-1是超氧化物歧化酶（SOD1）的抑制剂。
LCS-1是超氧化物歧化酶（SOD1）的抑制剂。 LCS-1抑制肺腺癌细胞系的增殖。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Shuai Li et al.
Cell communication and signaling : CCS, 16(1), 28-28 (2018-06-13)
SOD1 is an abundant enzyme that has been studied as a regulator of the antioxidant defence system, and this enzyme is well known for catalyzing the dismutation of superoxide into hydrogen peroxide. However the SOD1 in the progress of NPC
Aditi Mishra et al.
Scientific reports, 8(1), 901-901 (2018-01-19)
Extrinsic control of single neurons and neuronal populations is a powerful approach for understanding how neural circuits function. Adding new thermogenetic tools to existing optogenetic and other forms of intervention will increase the complexity of questions that can be addressed.
Ting Du et al.
Leukemia, 35(2), 550-561 (2020-05-20)
Our prior study showed that inhibition of 19S proteasome-associated ubiquitin receptor Rpn13 can overcome bortezomib resistance in MM cells. Here, we performed proteomic analysis of Rpn13 inhibitor (RA190)-treated MM cells and identified an antioxidant enzyme superoxide dismutase (SOD1) as a
Young-Ok Son et al.
The Journal of biological chemistry, 289(41), 28660-28675 (2014-08-27)
The cadmium-transformed human lung bronchial epithelial BEAS-2B cells exhibit a property of apoptosis resistance as compared with normal non-transformed BEAS-2B cells. The level of basal reactive oxygen species (ROS) is extremely low in transformed cells in correlation with elevated expressions
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