SML0468
多佐胺
≥98% (HPLC)
别名:
(4S,6S)-4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, 4S,6S-Dorzolamide, L-671,152, MK-507
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关于此项目
经验公式（希尔记法）:
C10H16N2O4S3
化学文摘社编号:
分子量:
324.44
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D -25 to -35°, c = 1 in methanol
color
white to beige
solubility
DMSO: 5 mg/mL (clear solution, warmed)
storage temp.
room temp
SMILES string
CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O
InChI
1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1
InChI key
IAVUPMFITXYVAF-XPUUQOCRSA-N
Gene Information
human ... CA2(760)
Biochem/physiol Actions
Dorzolamide is a potent carbonic anhydrase II inhibitor with an IC50 value of 0.16 nM on human erythrocyte carbonic anhydrase II in vitro. It has been found to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension.
Dorzolamide is a potent carbonic anhydrase II inhibitor.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
John S Sapienza et al.
Veterinary ophthalmology, 22(4), 520-528 (2018-10-26)
The purpose of this study was to report the preliminary results of a novel micropulse transscleral diode laser cyclophotocoagulation (MP-TSCP) as primary therapy for glaucomatous dogs. Client owned dogs undergoing MP-TSCP therapy at a veterinary referral center. Retrospective study of
Un Chul Park et al.
Retina (Philadelphia, Pa.), 40(7), 1359-1366 (2019-06-06)
To evaluate the efficacy and safety of intravitreal dexamethasone (DEX) implant in retinitis pigmentosa patients with cystoid macular edema (CME). In this randomized, noncontrolled, paired-eye, single crossover clinical trial, one eye of retinitis pigmentosa patients with bilateral CME with central
Daniel Laroche et al.
Journal of glaucoma, 27(10), e158-e161 (2018-07-26)
We describe a novel technique comprising the use of trypan blue to confirm aqueous outflow to collector channels and aqueous veins after goniotomy with the Kahook Dual Blade (New World Medical, Rancho Cucamonga, CA). Intraocular dyes have been safely used
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML0468-50MG | 04061833222942 |
| SML0468-10MG | 04061837084621 |