SML0468
多佐胺
≥98% (HPLC)
别名:
(4S,6S)-4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, 4S,6S-Dorzolamide, L-671,152, MK-507
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经验公式（希尔记法）:
C10H16N2O4S3
化学文摘社编号:
分子量:
324.44
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
多佐胺, ≥98% (HPLC)
InChI
1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1
SMILES string
CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O
InChI key
IAVUPMFITXYVAF-XPUUQOCRSA-N
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D -25 to -35°, c = 1 in methanol
color
white to beige
solubility
DMSO: 5 mg/mL (clear solution, warmed)
storage temp.
room temp
Quality Level
Gene Information
human ... CA2(760)
相关类别
Biochem/physiol Actions
Dorzolamide is a potent carbonic anhydrase II inhibitor with an IC50 value of 0.16 nM on human erythrocyte carbonic anhydrase II in vitro. It has been found to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension.
Dorzolamide is a potent carbonic anhydrase II inhibitor.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Ichiro Kawaguchi et al.
PloS one, 12(10), e0186714-e0186714 (2017-10-20)
This study aimed to determine if rebamipide eyedrops can improve ocular surface damage caused by the use of glaucoma eyedrops. Female Kbl:Dutch rabbits were used to evaluate glaucoma eyedrop-induced ocular surface damage; one eye of each rabbit was untreated and
Luciano Quaranta et al.
Journal of glaucoma, 26(11), 987-994 (2017-09-29)
To investigate the efficacy and safety of a treatment strategy with latanoprost and dorzolamide in primary pediatric glaucoma patients partially responsive to surgery. Children with primary pediatric glaucoma having postsurgical untreated intraocular pressure (IOP) between 22 and 26 mm Hg were eligible.
Rodolfo Mastropasqua et al.
Ophthalmic surgery, lasers & imaging retina, 49(9), e20-e31 (2018-09-18)
The aim of the study was to determine optical coherence tomography angiography (OCTA) findings and to identify mutations in the RS1 gene in a three-generation family with X-linked juvenile retinoschisis (XLRS). Clinical and genetic assessments were performed in 12 family
Yukari Yagi-Yaguchi et al.
Diagnostics (Basel, Switzerland), 10(1) (2020-01-08)
Anti-glaucoma eye drop treatment often induces dry eyes and can lead to poor medication adherence. This study aimed to investigate the effects of 3% diquafosol sodium eye drops on tear function and the ocular surface epithelium in Sod1-/- mice after
Riku P J Arvola et al.
Cornea, 35(4), 451-455 (2016-02-05)
Treating corneal neurotrophic ulcers is challenging. Topical application of matrix regeneration therapy (RGTA), which is a dextran derivative polymer and heparan sulfate analog, is a promising regenerative therapy and an alternative or additional therapeutic regimen when corneal healing is compromised.
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