SML0471
A22 盐酸盐
≥95% (HPLC), MreB inhibitor, powder
别名:
MreB干扰化合物A22, S-(3,4-二氯苄基)异硫脲 盐酸盐
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关于此项目
经验公式（希尔记法）:
C8H8Cl2N2S · HCl
化学文摘社编号:
分子量:
271.59
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
A22 盐酸盐, ≥95% (HPLC)
Quality Level
assay
≥95% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL (clear solution, warmed)
storage temp.
2-8°C
SMILES string
Cl.NC(=N)SCc1ccc(Cl)c(Cl)c1
InChI
1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(3-7(6)10)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H
InChI key
VBJNMXMOMSWRDV-UHFFFAOYSA-N
Application
A22盐酸已被用于研究其抗生物膜活性、抗菌、细胞和遗传毒性活性。它也可作为MreB聚合抑制剂用于了解MreB聚合物在白色念珠菌和高假丝酵母念珠菌中的作用。
Biochem/physiol Actions
A22是肌动蛋白样细菌蛋白MreB的一种抑制剂，已被证明可作为抗菌佐剂。
A22是肌动蛋白样细菌蛋白MreB的一种抑制剂，已被证明可作为抗菌佐剂。A22对MreB的抑制作用可破坏细菌肌动蛋白的细胞骨架，导致细胞通透性增加和干扰转运。A22已显示出与革兰氏阴性细菌中的数种抗生素具有协同作用，包括新生霉素和利福平。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Anti-biofilm activity of A22 ((S-3, 4-dichlorobenzyl) isothiourea hydrochloride) against Pseudomonas aeruginosa: Influence on biofilm formation, motility and bioadhesion.
Bonez P C, et al.
Microbial Pathogenesis, 111, 6-13 (2017)
Host-polarized cell growth in animal symbionts.
Pende N, et al.
Current Biology, 28(7), 1039-1051 (2018)
Alam García-Heredia et al.
eLife, 10 (2021-02-06)
Many antibiotics target the assembly of cell wall peptidoglycan, an essential, heteropolymeric mesh that encases most bacteria. In rod-shaped bacteria, cell wall elongation is spatially precise yet relies on limited pools of lipid-linked precursors that generate and are attracted to
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML0471-10MG | 04061832633527 |
| SML0471-50MG | 04061832633534 |