SML0476
Rabeprazole sodium
≥98% (HPLC)
别名:
2-([4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl)-1H-benzo[d]imidazole, Pariprazole
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关于此项目
经验公式（希尔记法）:
C18H20N3O3S · Na
化学文摘社编号:
分子量:
381.42
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 10 mg/mL (clear solution)
shipped in
wet ice
storage temp.
−20°C
SMILES string
[Na+].COCCCOc1ccnc(CS(=O)c2nc3ccccc3[n-]2)c1C
InChI
1S/C18H20N3O3S.Na/c1-13-16(19-9-8-17(13)24-11-5-10-23-2)12-25(22)18-20-14-6-3-4-7-15(14)21-18;/h3-4,6-9H,5,10-12H2,1-2H3;/q-1;+1
InChI key
KRCQSTCYZUOBHN-UHFFFAOYSA-N
Gene Information
human ... ATP4A(495), ATP4B(496)
Application
Rabeprazole sodium has been used as a proton pump inhibitor (PPI) to study its effects on spontaneous uterine contractile activity in pregnant women.
Biochem/physiol Actions
Rabeprazole sodium is gastric proton pump inhibitor. It suppresses the production of acid in the stomach by inhibiting the gastric H+/K+ATPase (hydrogen-potassium adenosine triphosphatase) at the secretory surface of the gastric parietal cell. Rabeprazole sodium has been used clinically to treat acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevent gastroinetestinal bleeds associated with NSAID use.
Rabeprazole sodium is gastric proton pump inhibitor; antiulcerative.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 4
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
C Terranova et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 52, 125-131 (2013-11-13)
In this study we investigate in in vitro myometrial tissue samples of pregnant women: (a) the effects of proton pomp inhibitors (PPIs) (omeprazole, esomeprazole, pantoprazole, lansoprazole and rabeprazole) on spontaneous contractions; (b) the muscle-relaxant efficacy of the most active PPI
Leonhard X Heinz et al.
Nature, 581(7808), 316-322 (2020-05-21)
Toll-like receptors (TLRs) have a crucial role in the recognition of pathogens and initiation of immune responses1-3. Here we show that a previously uncharacterized protein encoded by CXorf21-a gene that is associated with systemic lupus erythematosus4,5-interacts with the endolysosomal transporter
Increased gap density predicts weakness of the epithelial barrier in vivo by confocal laser endomicroscopy in indomethacin-induced enteropathy.
Shi S, Wang H, Gao H, et al.
Digestive Diseases and Sciences, 59(7), 1398-1405 (2014)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML0476-50MG | 04061832576251 |
| SML0476-10MG | 04061837084638 |