SML0488
苯磺酸硅钙
≥98% (HPLC), fibroblast growth factor (FGF) inhibitor, powder
别名:
2,5-Dihydroxybenzenesulfonic acid calcium salt, 205E, Calcium 2,5-dihydroxybenzenesulfonate, Calcium Dobesilate, Hydroquinone calcium sulfonate
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关于此项目
经验公式（希尔记法）:
C6H5O5S · 0.5Ca
化学文摘社编号:
分子量:
209.20
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
苯磺酸硅钙, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
H2O: 15 mg/mL, clear
储存温度
room temp
SMILES字符串
[Ca++].Oc1ccc(O)c(c1)S([O-])(=O)=O.Oc2ccc(O)c(c2)S([O-])(=O)=O
InChI
1S/2C6H6O5S.Ca/c2*7-4-1-2-5(8)6(3-4)12(9,10)11;/h2*1-3,7-8H,(H,9,10,11);/q;;+2/p-2
InChI key
QGNBTYAQAPLTMX-UHFFFAOYSA-L
一般描述
Dobesilate calcium belongs to the family of fibroblast growth factor (FGF) inhibitors.
应用
Dobesilate calcium has been used to study its interference in different in vitro assay systems for the determination of creatinine, uric acid, cholesterol, and triglycerides.
生化/生理作用
Dobesilate Calcium is a vasoprotectant used as a treatment for chronic venous disease, diabetic retinopathy and other microvascular disorders. Its mechanism of action is not fully understood. It appears that dobesilate calcium increases endothelial nitric oxide levels by enhancing the activity of nitric oxide synthase and decreasing capillary hyperpermeability. Also in diabetic retinopathy dobesilate calcium prevents the blood-retinal barrier breakdown induced by diabetes by restoration of the tight junction protein, and decreasing the leukocyte adhesion to retinal vessels.
Dobesilate Calcium is a vasoprotectant.
Dobesilate calcium inhibits the action of fibroblast growth factor by binding to its heparin-binding domain. It is also useful in treating rosacea and psoriasis, characterized with uncontrolled angiogenesis and vascular endothelial growth factor overexpression.
特点和优势
This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Negative interferences by calcium dobesilate in the detection of five serum analytes involving Trinder reaction-based assays.
Guo X, et al.
PLoS ONE, 13(2), e0192440-e0192440 (2018)
Xiuzhi Guo et al.
Clinica chimica acta; international journal of clinical chemistry, 483, 1-5 (2018-04-14)
We reported that calcium dobesilate, a vasoprotective agent mainly used for diabetic retinopathy (DR), negatively interferes with glycated albumin (GA) assays involving enzymatic methods. A calcium dobesilate standard was added to 3serum pools in vitro to prepare concentration-response series according
Xiuzhi Guo et al.
Medicine, 94(23), e905-e905 (2015-06-11)
The vasoprotective drug calcium dobesilate is known to interfere with creatinine (Cr) quantifications in sarcosine oxidase enzymatic (SOE) assays. The aim of this study was to investigate this interference in 8 different commercially available assays and to determine its clinical
Therapeutic effects of calcium dobesilate on diabetic nephropathy mediated through reduction of expression of PAI?1.
Zhang X
Experimental and Therapeutic Medicine, 5(1), 295-299 (2013)
Jaimi A Gray et al.
BMC evolutionary biology, 19(1), 7-7 (2019-01-10)
Morphological diversity among closely related animals can be the result of differing growth patterns. The Australian radiation of agamid lizards (Amphibolurinae) exhibits great ecological and morphological diversity, which they have achieved on a continent-wide scale, in a relatively short period
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