SML0488
苯磺酸硅钙
≥98% (HPLC), fibroblast growth factor (FGF) inhibitor, powder
别名:
Calcium Dobesilate, 2,5-Dihydroxybenzenesulfonic acid calcium salt, 205E, Calcium 2,5-dihydroxybenzenesulfonate, Hydroquinone calcium sulfonate
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关于此项目
经验公式（希尔记法）:
C6H5O5S · 0.5Ca
化学文摘社编号:
分子量:
209.20
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
苯磺酸硅钙, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 15 mg/mL, clear
storage temp.
room temp
SMILES string
[Ca++].Oc1ccc(O)c(c1)S([O-])(=O)=O.Oc2ccc(O)c(c2)S([O-])(=O)=O
InChI
1S/2C6H6O5S.Ca/c2*7-4-1-2-5(8)6(3-4)12(9,10)11;/h2*1-3,7-8H,(H,9,10,11);/q;;+2/p-2
InChI key
QGNBTYAQAPLTMX-UHFFFAOYSA-L
General description
Dobesilate calcium belongs to the family of fibroblast growth factor (FGF) inhibitors.
Application
Dobesilate calcium has been used to study its interference in different in vitro assay systems for the determination of creatinine, uric acid, cholesterol, and triglycerides.
Biochem/physiol Actions
Dobesilate calcium inhibits the action of fibroblast growth factor by binding to its heparin-binding domain. It is also useful in treating rosacea and psoriasis, characterized with uncontrolled angiogenesis and vascular endothelial growth factor overexpression.
Dobesilate Calcium is a vasoprotectant used as a treatment for chronic venous disease, diabetic retinopathy and other microvascular disorders. Its mechanism of action is not fully understood. It appears that dobesilate calcium increases endothelial nitric oxide levels by enhancing the activity of nitric oxide synthase and decreasing capillary hyperpermeability. Also in diabetic retinopathy dobesilate calcium prevents the blood-retinal barrier breakdown induced by diabetes by restoration of the tight junction protein, and decreasing the leukocyte adhesion to retinal vessels.
Dobesilate Calcium is a vasoprotectant.
Features and Benefits
This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Therapeutic effects of calcium dobesilate on diabetic nephropathy mediated through reduction of expression of PAI?1.
Zhang X
Experimental and Therapeutic Medicine, 5(1), 295-299 (2013)
T H Witney et al.
British journal of cancer, 103(9), 1400-1406 (2010-10-07)
The recent introduction of a dynamic nuclear polarisation technique has permitted noninvasive imaging of tumour cell metabolism in vivo following intravenous administration of (13)C-labelled cell substrates. Changes in hyperpolarised [1-(13)C]pyruvate and [1,4-(13)C(2)]fumarate metabolism were evaluated in both MDA-MB-231 cells and
Xiuzhi Guo et al.
Medicine, 94(23), e905-e905 (2015-06-11)
The vasoprotective drug calcium dobesilate is known to interfere with creatinine (Cr) quantifications in sarcosine oxidase enzymatic (SOE) assays. The aim of this study was to investigate this interference in 8 different commercially available assays and to determine its clinical
Alireza Javadzadeh et al.
Molecular vision, 19, 62-68 (2013-01-22)
To determine the benefits of calcium dobesilate (CaD) administration on endothelial function and inflammatory status in patients with diabetic retinopathy through measurement of serum levels of endothelin-1 and high-sensitivity C-reactive protein (hsCRP). In a double-blind, randomized clinical trial, 90 patients
Varut Lohsiriwat
World journal of gastroenterology, 18(17), 2009-2017 (2012-05-09)
This review discusses the pathophysiology, epidemiology, risk factors, classification, clinical evaluation, and current non-operative and operative treatment of hemorrhoids. Hemorrhoids are defined as the symptomatic enlargement and distal displacement of the normal anal cushions. The most common symptom of hemorrhoids
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML0488-10MG | 04061837084676 |
| SML0488-50MG | 04061833223000 |
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