SML0493
T16Ainh-A01
≥95% (HPLC)
别名:
2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]-acetamide
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选择尺寸
关于此项目
经验公式（希尔记法）:
C19H20N4O3S2
化学文摘社编号:
分子量:
416.52
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
T16Ainh-A01, ≥95% (HPLC)
InChI
1S/C19H20N4O3S2/c1-4-14-11(2)20-18(23-17(14)25)28-10-16(24)22-19-21-15(9-27-19)12-5-7-13(26-3)8-6-12/h5-9H,4,10H2,1-3H3,(H,20,23,25)(H,21,22,24)
SMILES string
CCc1c(C)nc(SCC(=O)Nc2nc(cs2)-c3ccc(OC)cc3)nc1O
InChI key
QSIYTNYMBWYHAA-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
room temp
Quality Level
相关类别
Application
T16Ainh-A01 已被用作跨膜蛋白 16A (TMEM16A) 的抑制剂。
Biochem/physiol Actions
T16Ainh-A01 是一种选择性 TMEM16A 钙激活氯离子通道抑制剂，可强烈抑制唾液腺细胞的氯电流。T16Ainh-A01 对肠道和气道上皮细胞的总 CaCC 电流的抑制作用较差，但主要阻断初始的、激动剂刺激的瞬时氯电流。T16Ainh-A01 不改变胞浆钙离子，对 CFTR Cl-电导几乎没有影响。
T16Ainh-A01 是选择性 TMEM16A 钙激活氯离子通道抑制剂...
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
TMEM16A regulates portal vein smooth muscle cell proliferation in portal hypertension.
Zeng X, et al.
Experimental and Therapeutic Medicine, 15(1), 1062-1068 (2018)
Jinyu Zhang et al.
International journal of molecular sciences, 23(22) (2022-11-27)
Dry eye disease (DED) is a multifactorial disease with an incidence of approximately 50% worldwide. DED seriously affects quality of life and work. The prevalence of environmental DED (eDED) ranges from 35 to 48%. Conjunctival fluid secretion dysfunction may be
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