SML0499
NCTT-956
≥97% (NMR)
别名:
N-[(8-Hydroxy-5-nitro-7-quinolinyl)-2-thienylmethyl]-propanamide
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C17H15N3O4S
化学文摘社编号:
分子量:
357.38
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
产品名称
NCTT-956, ≥97% (NMR)
InChI key
DEXNORPUTBBNSC-UHFFFAOYSA-N
SMILES string
CCC(=O)NC(c1cccs1)c2cc([N+]([O-])=O)c3cccnc3c2O
InChI
1S/C17H15N3O4S/c1-2-14(21)19-15(13-6-4-8-25-13)11-9-12(20(23)24)10-5-3-7-18-16(10)17(11)22/h3-9,15,22H,2H2,1H3,(H,19,21)
assay
≥97% (NMR)
form
powder
color
light orange to dark orange
solubility
DMSO: 5 mg/mL (clear solution)
storage temp.
2-8°C
Quality Level
相关类别
Biochem/physiol Actions
NCTT-956 is a potent, specific 12-LO inhibitor.
NCTT-956 is a very potent, specific inhibitor of 12-lipoxygenase (12-LO) activity, with an IC50 of 800 nM, no activity against 5-LO and greater than 25-fold selectivity over 15-LO. Specific inhibition of 12-LO by NCTT-956 in platelets blocks PKC activation, aggregation, granule secretion and αIIbB3 activation.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Luiz Osório Leiria et al.
Cell metabolism, 30(4), 768-783 (2019-07-30)
Distinct oxygenases and their oxylipin products have been shown to participate in thermogenesis by mediating physiological adaptations required to sustain body temperature. Since the role of the lipoxygenase (LOX) family in cold adaptation remains elusive, we aimed to investigate whether
Lisa Mayr et al.
Nature communications, 11(1), 1775-1775 (2020-04-15)
The increased incidence of inflammatory bowel disease (IBD) has become a global phenomenon that could be related to adoption of a Western life-style. Westernization of dietary habits is partly characterized by enrichment with the ω-6 polyunsaturated fatty acid (PUFA) arachidonic
Dennis Y Chuang et al.
Journal of neuroinflammation, 12, 199-199 (2015-11-02)
Oxidative stress and inflammation are important factors contributing to the pathophysiology of numerous neurological disorders, including Alzheimer's disease, Parkinson's disease, acute stroke, and infections of the brain. There is well-established evidence that proinflammatory cytokines and glutamate, as well as reactive
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持