SML0505
钛酸
≥98% (HPLC), P450 inhibitor, powder
别名:
[2,3-二氯-4-(2-噻吩基羰基)苯氧基]-乙酸, 替尼酸, 烯酸
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关于此项目
经验公式（希尔记法）:
C13H8Cl2O4S
化学文摘社编号:
分子量:
331.17
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12161501
EC Number:
254-826-3
MDL number:
产品名称
钛酸, ≥98% (HPLC)
InChI key
AGHANLSBXUWXTB-UHFFFAOYSA-N
InChI
1S/C13H8Cl2O4S/c14-11-7(13(18)9-2-1-5-20-9)3-4-8(12(11)15)19-6-10(16)17/h1-5H,6H2,(H,16,17)
SMILES string
OC(=O)COc1ccc(c(Cl)c1Cl)C(=O)c2cccs2
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL (clear solution)
shipped in
wet ice
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
替尼酸（Ticrynafen）是一种P450抑制剂，是CYP2C9和CYP2C10的一种特异性自杀底物。
替尼酸（Ticrynafen）是一种P450抑制剂，是CYP2C9和CYP2C10的一种特异性自杀底物。它曾经被用作具有降尿酸（增加尿酸排泄）活性的利尿药，但由于其肝毒性而被市场淘汰。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Takayoshi Nishiya et al.
Toxicology letters, 183(1-3), 81-89 (2008-11-11)
Tienilic acid is reported to be converted into electrophilic metabolites by cytochrome P450 (CYP) in vitro. In vivo, however, the metabolites have not been detected and their effect on liver function is unknown. We previously demonstrated that tienilic acid decreased
Mahendra Ramesh Shiradkar et al.
Bioorganic & medicinal chemistry, 15(19), 6397-6406 (2007-07-24)
Based on the earlier results of our in-house database and compound library, a series of novel clubbed thienyl triazoles was designed which may emerge as potential cdk5/p25 inhibitors, for the treatment of Alzheimer's disease. A benign synthesis was planned so
E Bonierbale et al.
Chemical research in toxicology, 12(3), 286-296 (1999-03-17)
Tienilic acid (TA) is responsible for an immune-mediated drug-induced hepatitis in humans, while its isomer (TAI) triggers a direct hepatitis in rats. In this study, we describe an immunological approach developed for studying the specificity of the covalent binding of
Yakov M Koen et al.
Chemical research in toxicology, 25(5), 1145-1154 (2012-04-03)
Tienilic acid (TA) is a uricosuric diuretic that was withdrawn from the market only months after its introduction because of reports of serious incidents of drug-induced liver injury including some fatalities. Its hepatotoxicity is considered to be primarily immunoallergic in
S Poli-Scaife et al.
Biochemistry, 36(42), 12672-12682 (1997-10-23)
Purified recombinant human liver cytochrome P450 2C9 was produced, from expression of the corresponding cDNA in yeast, in quantities large enough for UV-visible and 1H NMR experiments. Its interaction with several substrates (tienilic acid and two derivatives, lauric acid and
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