SML0508
Pentostatin
≥95% (HPLC), adenosine deaminase inhibitor, powder
别名:
(8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, 2′-dCF, DCF, Deoxycoformycin
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关于此项目
经验公式（希尔记法）:
C11H16N4O4
化学文摘社编号:
分子量:
268.27
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
powder
Storage condition:
desiccated
产品名称
Pentostatin, ≥95% (HPLC)
Quality Segment
assay
≥95% (HPLC)
form
powder
optical activity
[α]/D +70 to +80°, c = 1 in H2O
storage condition
desiccated
color
white to beige
solubility
H2O: 10 mg/mL, clear
shipped in
wet ice
storage temp.
−20°C
SMILES string
OC[C@H]1O[C@H](C[C@@H]1O)n2cnc3[C@H](O)CN=CNc23
InChI
1S/C11H16N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-9,16-18H,1-3H2,(H,12,13)/t6-,7+,8+,9+/m0/s1
InChI key
FPVKHBSQESCIEP-JQCXWYLXSA-N
Gene Information
human ... ADA(100)
Application
Pentostatin has been used in in vivo anti-tumor studies. It has also been used along with cyclophosphamide as a selective B-cell immune suppression regimen to explore solid tumor therapy by selectively targeting stromal endothelial cells.
Biochem/physiol Actions
Pentostatin/2′-deoxycoformycin is used to treat patients with Waldenström′s macroglobulinemia.
Pentostatin is a ring-expanded nucleoside (REN) that potently inhibits adenosine deaminase, which leads to lymphocyte toxicity. Pentostatin is used as anticancer agent to treat leukemia (hairy cell leukemia and chronic lymphocytic leukemia) and is investigated as an agent to treat graft-versus-host disease (GVHD).
Pentostatin is an immunosuppressant; adenosine deaminase inhibitor; ring-expanded nucleoside (REN).
Features and Benefits
This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Other Notes
Air sensitve; hygroscopic.
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable