BIO-Acetoxime

Name: BIO-Acetoxime
Brand: SIGMA

≥98% (HPLC)

别名:

(2′Z,3′E)-6-Bromoindirubin-3′-acetoxime, (3Z)-3-[(3E)-3-[(Acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-2H-Indol-2-one, 6-Bromoindirubin acetoxime, 6-Bromoindirubin-3′-acetoxime, BIA

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所有图片(1)

About This Item

经验公式（希尔记法）:

C₁₈H₁₂BrN₃O₃

CAS Number:

667463-85-6

分子量:

398.21

MDL编号:

MFCD09037533

UNSPSC代码:

12352200

PubChem化学物质编号:

329825535

NACRES:

NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

, dark red to purple

溶解性

H₂O: 2 mg/mL (clear solution, warmed)

储存温度

2-8°C

SMILES字符串

CC(=O)O\N=C1\C(Nc2ccccc12)=C3\C(=O)Nc4cc(Br)ccc34

InChI

1S/C18H12BrN3O3/c1-9(23)25-22-16-12-4-2-3-5-13(12)20-17(16)15-11-7-6-10(19)8-14(11)21-18(15)24/h2-8,20H,1H3,(H,21,24)/b17-15-,22-16+

InChI key

MENDIXKFTXYTHJ-HPBPSMLHSA-N

生化/生理作用

BIO-Acetoxime is a potent and selective GSK-3a/b inhibitor that reduces invasiveness of gliomas and extends animal survival in intracranial glioma models. Also, BIO-Acetoxime induces Wnt signaling and inhibits CD8+ T cell effector differentiation.

BIO-Acetoxime is a potent and selective GSK-3a/b inhibitor.

特点和优势

This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.