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Merck
CN

SML0535

Sigma-Aldrich

舒芬太尼标准液

≥98% (HPLC)

别名:

N-[4-(Methoxymethyl)-1-[2-(2-thienyl)ethyl]-4-piperidinyl]-N-phenylpropanamide citrate, R-33800, Sufentanyl citrate

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关于此项目

经验公式（希尔记法）:
C22H30N2O2S · C6H8O7
化学文摘社编号:
60561-17-3
分子量:
578.67
EC 号:
262-295-4
UNSPSC代码:
12352200
NACRES:
NA.77

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质量水平

100

方案

≥98% (HPLC)

表单

powder

药品控制

USDEA Schedule II; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

储存条件

desiccated

颜色

white to beige

溶解性

H2O: 1 mg/mL, clear

储存温度

2-8°C

SMILES字符串

[s]1c(ccc1)CCN2CCC(CC2)(N(c3ccccc3)C(=O)CC)COC.OC(CC(=O)O)(CC(=O)O)C(=O)O

InChI

1S/C22H30N2O2S.C6H8O7/c1-3-21(25)24(19-8-5-4-6-9-19)22(18-26-2)12-15-23(16-13-22)14-11-20-10-7-17-27-20;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-10,17H,3,11-16,18H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

InChI key

OJCZPLDERGDQRJ-UHFFFAOYSA-N

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生化/生理作用

Sufentanil is a mu-opioid receptor agonist; analgesic; anesthesia adjunct.
Sufentanil is a mu-opioid selective agonist, 10 times more potent than fentanyl, over 1000 times more potent than morphine. Sufentanil citrate is used as an analgesic and anesthesia adjunct. There are some differences in activity and selectivity among the mu-opiate agonist analgesics. Receptor-internalizing agonists like beta-endorphin, methadone, fentanyl, and sufentanil have been found to induce NADH/NADPH-mediated reactive oxygen species (ROS) synthesis via Phospholipase D-dependent signaling pathways whereas agonists like morphine that do not induce receptor endocytosis failed to activate ROS synthesis. In another report meperidine, remifentanil and tramadol were found to interact with alpha(2)-adrenoceptors, whereas sufentanil did not.

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H300 + H310 + H330

危险分类

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000018502
0000019344
073M4726V

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Criteria for use of fentanyl citrate, sufentanil citrate, and alfentanil hydrochloride.
G B Satterlee et al.
Clinical pharmacy, 10(8), 635-637 (1991-08-01)
C E Rosow
Pharmacotherapy, 4(1), 11-19 (1984-01-01)
Sufentanil citrate is a potent analogue of fentanyl that has been evaluated primarily for use in opioid anesthesia. It is a pure mu receptor agonist and produces the typical spectrum of opioid effects. The major side effects are truncal rigidity
T I Saari et al.
British journal of anaesthesia, 113(4), 677-687 (2014-07-09)
Our objective was to evaluate the effect of intensive care treatment on the protein binding of sufentanil and hydromorphone in cardiac surgery patients during postoperative analgesia using a target-controlled infusion (TCI) and patient-controlled analgesia (PCA). Fifty adult patients were enrolled

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